Evidence map›Paper›PMID 23537891›Full record

ArticleAmerican journal of hypertension2013

Associations of aortic distensibility and arterial elasticity with long-term visit-to-visit blood pressure variability: the Multi-Ethnic Study of Atherosclerosis (MESA).

Daichi Shimbo, Steven Shea, Robyn L McClelland, Anthony J Viera, Devin Mann, Jonathan Newman, Joao Lima, Joseph F Polak, Bruce M Psaty, Paul Muntner

Abstract readComparative StudyMulticenter Study
In one paragraph

Article in American journal of hypertension, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
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  7. Article
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  14. Long-Term Blood Pressure Variability and Physical Performance in Older Adults.Journal of clinical hypertension (Greenwich, Conn.) · 2025
    Observational
  15. Article
  16. Impact of Variability in Blood Pressure and Heart Rate on Beta-Blocker Adherence.Journal of clinical hypertension (Greenwich, Conn.) · 2025
    Article
  17. Article
  18. Article
  19. Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daichi ShimboDepartment of Medicine, Columbia University Medical Center, New York, New York, USA. ds2231@mail.cumc.columbia.edu
Steven Shea
Robyn L McClelland
Anthony J Viera
Devin Mann
Jonathan Newman
Joao Lima
Joseph F Polak
Bruce M Psaty
Paul Muntner

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
POSTDOCTORAL TRAINING IN CARDIOVASCULAR DISEASET32HL007854 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Marwah Abdalla, Michael Argenziano · 1996 to 2026
$14.7M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
LC-based Nitric Oxide Breath Monitor for Asthma ManagementR43HL095167 · NHLBI · PLATYPUS TECHNOLOGIES, LLC · PI SEN, AVIJIT · 2009 to 2010
$400k
SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-N01HC95159-268095159N01HC095159 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 1999 to 2006
$304k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-ULTRASOUNDN01HC095167 · HC · TUFTS MEDICAL CENTER · PI O'LEARY, DANIEL H. · 1999 to 2001
$62k
2009 Nitric Oxide Gordon Research ConferenceR13HL095166 · NHLBI · GORDON RESEARCH CONFERENCES · PI STUEHR, DENNIS J · 2009 to 2009
$15k
NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1RR024156NHLBI NIH HHS 5T32HL007854-16NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95166NHLBI NIH HHS N01-HC-95167NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01-HL077612NHLBI NIH HHS T32 HL007854
6 · The paper itself

Abstract

backgroundAlthough higher visit-to-visit variability (VVV) of blood pressure (BP) is associated with increased cardiovascular disease risk, the physiological basis for VVV of BP is incompletely understood.

methodsWe examined the associations of aortic distensibility (assessed by magnetic resonance imaging) and artery elasticity indices (determined by radial artery pulse contour analysis) with VVV of BP in 2,640 and 4,560 participants, respectively, from the Multi-Ethnic Study of Atherosclerosis. Arterial measures were obtained at exam 1. BP readings were taken at exam 1 and at 3 follow-up visits at 18-month intervals (exams 2, 3, and 4). VVV was defined as the SD about each participant's mean systolic BP (SBP) across visits.

resultsThe mean SDs of SBP were inversely associated with aortic distensibility: 7.7, 9.9, 10.9, and 13.2mm Hg for quartiles 4, 3, 2, and 1 of aortic distensibility, respectively (P trend < 0.001). This association remained significant after adjustment for demographics, cardiovascular risk factors, mean SBP, and antihypertensive medication use (P trend < 0.01). In a fully adjusted model, lower quartiles of large artery and small artery elasticity (LAE and SAE) indices were also associated with higher mean SD of SBP (P trend = 0.02 for LAE; P trend < 0.001 for SAE).

conclusionsIn this multiethnic cohort, functional alterations of central and peripheral arteries were associated with greater long-term VVV of SBP.

Indexed as

EthnicityAgedAged, 80 and overAorta, ThoracicArteriesAtherosclerosisBlood PressureElasticityFemaleFollow-Up StudiesHumansMagnetic Resonance Imaging, CineMaleMiddle AgedPrevalenceRisk Factorsarteriesblood pressureepidemiologyhypertensionvasculature.

Identifiers

PMID23537891
PMCPMC3693480

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.