Evidence map›Paper›PMID 23537801›Full record

ArticleThe Lancet. Infectious diseases2013

Community viral load as a measure for assessment of HIV treatment as prevention.

William C Miller, Kimberly A Powers, M Kumi Smith, Myron S Cohen

Abstract read
In one paragraph

Article in The Lancet. Infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Community viral load and hepatitis C virus infection: Community viral load measures to aid public health treatment efforts and program evaluation.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020
    Pooled it
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  12. Commentary on Quigley et al.Physiotherapy Canada. Physiotherapie Canada · 2024
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

William C MillerDivision of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. bill_miller@unc.edu
Kimberly A Powers
M Kumi Smith
Myron S Cohen

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Training in Sexually Transmitted Infections and HIVT32AI007001 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SENA-SOBERANO, ARLENE C. · 1985 to 2025
$10.9M
Acute HIV infection - A key link for transmission preventionR01AI083059 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MILLER, WILLIAM C, PETTIFOR, AUDREY · 2009 to 2012
$3.7M
HIV IN SEMEN-EFFECTS OF STDS AND ANTIVIRAL THERAPYR37DK049381 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COHEN, MYRON SCOTT · 2005 to 2014
$3.4M
HIV IN SEMEN--EFFECTS OF STDS AND ANTIVIRAL THERAPYR01DK049381 · NIDDK · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI COHEN, MYRON S · 1996 to 2004
$2.2M
NIAID NIH HHS P30 AI050410NIAID NIH HHS R01 AI083059NIAID NIH HHS R01AI083059NIAID NIH HHS T32 AI007001NIAID NIH HHS T32AI007001NIDDK NIH HHS R01 DK049381NIDDK NIH HHS R37 DK049381NIDDK NIH HHS R37DK049381
6 · The paper itself

Abstract

Community viral load, defined as an aggregation of individual viral loads of people infected with HIV in a specific community, has been proposed as a useful measure to monitor HIV treatment uptake and quantify its effect on transmission. The first reports of community viral load were published in 2009, and the measure was subsequently incorporated into the US National HIV/AIDS Strategy. Although intuitively an appealing strategy, measurement of community viral load has several theoretical limitations and biases that need further assessment, which can be grouped into four categories: issues of selection and measurement, the importance of HIV prevalence in determining the potential for ongoing HIV transmission, interpretation of community viral load and its effect on ongoing HIV transmission in a community, and the ecological fallacy (ie, ecological bias). These issues need careful assessment as community viral load is being considered as a public health measurement to assess the effect of HIV care on prevention.

Indexed as

Viral LoadAnti-Retroviral AgentsDatabases, FactualDisease Transmission, InfectiousHIVHIV InfectionsHumansPopulation SurveillancePrevalenceSexual BehaviorTime FactorsAnti-Retroviral Agents

Identifiers

PMID23537801
PMCPMC4512165

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.