ReviewCritical care clinics2013
Pediatric sepsis: challenges and adjunctive therapies.
Review in Critical care clinics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Immunomodulation in Pediatric Sepsis: A Narrative Review.Journal of clinical medicine · 2025Review
- Impact of CytoSorb and CKRT on hemodynamics in pediatric patients with septic shock: the PedCyto study.Frontiers in pediatrics · 2023Article
- Thrombocytopenia and Bloodstream Infection: Incidence and Implication on Length of Stay in the Pediatric Intensive Care Unit.Journal of pediatric intensive care · 2022Article
- Biomarker combinations in predicting sepsis in hospitalized children with fever.BMC pediatrics · 2022Article
- Surface TREM-1 as a Prognostic Biomarker in Pediatric Sepsis.Indian journal of pediatrics · 2021Observational
- Barriers and Proposed Solutions to a Successful Implementation of Pediatric Sepsis Protocols.Frontiers in pediatrics · 2021Review
- Interventions for Pediatric Sepsis and Their Impact on Outcomes: A Brief Review.Healthcare (Basel, Switzerland) · 2018Review
- Hypofibrinogenemia Is Associated With Poor Outcome and Secondary Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome in Pediatric Severe Sepsis.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2018Observational
- Salivary biomarkers may measure stress responses in critically ill children.SAGE open medicine · 2018Article
- Glucocorticoid Receptor Polymorphisms and Outcomes in Pediatric Septic Shock.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Article
- Olfactomedin-4 Is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock.Critical care medicine · 2017Article
- Pediatric Sepsis Biomarker Risk Model-II: Redefining the Pediatric Sepsis Biomarker Risk Model With Septic Shock Phenotype.Critical care medicine · 2016Article
- Glucocorticoid Receptor Expression in Peripheral WBCs of Critically Ill Children.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2015Article
- Outcomes of pediatric patients with abdominal sepsis requiring surgery and extracorporeal membrane oxygenation using the Extracorporeal Life Support Organization database.The American surgeon · 2015Article
- Developing a clinically feasible personalized medicine approach to pediatric septic shock.American journal of respiratory and critical care medicine · 2015Article
- Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults.Journal of critical care · 2014Article
- Identifying critically ill patients who may benefit from adjunctive corticosteroids: not as easy as we thought.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2014Article
- The pediatric sepsis biomarker risk model: potential implications for sepsis therapy and biology.Expert review of anti-infective therapy · 2014Review
- Corticosteroids are associated with repression of adaptive immunity gene programs in pediatric septic shock.American journal of respiratory and critical care medicine · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Sepsis remains an important challenge in pediatric critical care medicine. This review provides an appraisal of adjunctive therapies for sepsis and highlights opportunities for meeting selected challenges in the field. Future clinical studies should address long-term and functional outcomes as well as acute outcomes. Potential adjunctive therapies such as corticosteroids, hemofiltration, hemoadsorption, and plasmapheresis may have important roles, but still require formal and more rigorous testing by way of clinical trials. Finally, the design of future clinical trials should consider novel approaches for stratifying outcome risks as a means of improving the risk-to-benefit ratio of experimental therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.