ArticleBMC immunology2013
BATF regulates the development and function of IL-17 producing iNKT cells.
Article in BMC immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- BATF promotes group 2 innate lymphoid cell-mediated lung tissue protection during acute respiratory virus infection.Science immunology · 2022Article
- STAT5 Represses a STAT3-Independent Th17-like Program during Th9 Cell Differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Retroviral Transduction of NKT Hybridoma Cells.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Construction of a risk score prognosis model based on hepatocellular carcinoma microenvironment.World journal of gastroenterology · 2020Article
- The differentiation of ROR-γt expressing iNKT17 cells is orchestrated by Runx1.Scientific reports · 2017Article
- The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells.Nature immunology · 2017Article
- GWAS analysis implicates NF-κB-mediated induction of inflammatory T cells in multiple sclerosis.Genes and immunity · 2016Article
- Stress-activated Dendritic Cells (DC) Induce Dual Interleukin (IL)-15- and IL1β-mediated Pathways, Which May Elicit CD4+ Memory T Cells and Interferon (IFN)-stimulated Genes.The Journal of biological chemistry · 2015Article
- Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs.Frontiers in genetics · 2015Review
- Specificity through cooperation: BATF-IRF interactions control immune-regulatory networks.Nature reviews. Immunology · 2013Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBATF plays important roles in the function of the immune system. Batf null mice are deficient in both CD4+ Th17 cells and T follicular helper cells and possess an intrinsic B cell defect that leads to the complete absence of class switched Ig. In this study, Tg mice overexpressing BATF in T cells were used together with Batf null mice to investigate how altering levels of BATF expression in T cells impacts the development and function of a recently characterized population of iNKT cells expressing IL-17 (iNKT-17).
resultsBATF has a direct impact on IL-17 expression by iNKT cells. However, in contrast to the Th17 lineage where BATF activates IL-17 expression and leads to the expansion of the lineage, BATF overexpression restricts overall iNKT cell numbers while skewing the compartment in vivo and in vitro toward an iNKT-17 phenotype.
conclusionsThis work is the first to demonstrate that BATF joins RORγt as the molecular signature for all IL-17 producing cells in vivo and identifies BATF as a component of the nuclear protein network that could be targeted to regulate IL-17-mediated disease. Interestingly, these studies also reveal that while the Il17a gene is a common target for BATF regulation in Th17 and iNKT-17 cells, this regulation is accompanied by opposite effects on the growth and expansion of these two cell lineages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.