ArticlePloS one2013
Evaluating GWAS-identified SNPs for age at natural menopause among chinese women.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Pattern Recognition by NOD-Like Receptors.Advances in experimental medicine and biology · 2025Review
- Hematological Indices and Genetic Variants of Premature Ovarian Insufficiency: Machine Learning Approaches.Cardiovascular & hematological disorders drug targets · 2024Article
- Genetic Determinants of Premature Menopause in A Mashhad Population Cohort.International journal of fertility & sterility · 2021Article
- Is menopause still evolving? Evidence from a longitudinal study of multiethnic populations and its relevance to women's health.BMC women's health · 2020Article
- The NLR family pyrin domain-containing 11 protein contributes to the regulation of inflammatory signaling.The Journal of biological chemistry · 2018Article
- Complex genetics of female fertility.NPJ genomic medicine · 2018Review
- Genetic variants of age at menopause are not related to timing of ovarian failure in breast cancer survivors.Menopause (New York, N.Y.) · 2017Article
- Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample.Menopause (New York, N.Y.) · 2017Article
- Article
- Age at menarche and age at natural menopause in East Asian women: a genome-wide association study.Age (Dordrecht, Netherlands) · 2016Article
- Ovarian Physiology and GWAS: Biobanks, Biology, and Beyond.Trends in endocrinology and metabolism: TEM · 2016Review
- Genetics of the ovarian reserve.Frontiers in genetics · 2015Review
- Approaches to identify genetic variants that influence the risk for onset of fragile X-associated primary ovarian insufficiency (FXPOI): a preliminary study.Frontiers in genetics · 2014Article
- Genomic markers of ovarian reserve.Seminars in reproductive medicine · 2013Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAge at natural menopause (ANM) is a complex trait with high heritability and is associated with several major hormonal-related diseases. Recently, several genome-wide association studies (GWAS), conducted exclusively among women of European ancestry, have discovered dozens of genetic loci influencing ANM. No study has been conducted to evaluate whether these findings can be generalized to Chinese women. METHODOLOGY/PRINCIPAL
findingsWe evaluated the index single nucleotide polymorphisms (SNPs) in 19 GWAS-identified genetic susceptibility loci for ANM among 3,533 Chinese women who had natural menopause. We also investigated 3 additional SNPs which were in LD with the index SNP in European-ancestry but not in Asian-ancestry populations. Two genetic risk scores (GRS) were calculated to summarize SNPs across multiple loci one for all SNPs tested (GRSall), and one for SNPs which showed association in our study (GRSsel). All 22 SNPs showed the same association direction as previously reported. Eight SNPs were nominally statistically significant with P≤0.05: rs4246511 (RHBDL2), rs12461110 (NLRP11), rs2307449 (POLG), rs12611091 (BRSK1), rs1172822 (BRSK1), rs365132 (UIMC1), rs2720044 (ASH2L), and rs7246479 (TMEM150B). Especially, SNPs rs4246511, rs365132, rs1172822, and rs7246479 remained significant even after Bonferroni correction. Significant associations were observed for GRS. Women in the highest quartile began menopause 0.7 years (P = 3.24×10(-9)) and 0.9 years (P = 4.61×10(-11)) later than those in the lowest quartile for GRSsel and GRSall, respectively.
conclusionsAmong the 22 investigated SNPs, eight showed associations with ANM (P<0.05) in our Chinese population. Results from this study extend some recent GWAS findings to the Asian-ancestry population and may guide future efforts to identify genetic determination of menopause.
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