ArticlePloS one2013
A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel Loci.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Glaucoma Genetic Risk Scores in the Million Veteran Program.Ophthalmology · 2022Pooled it
- Apolipoprotein E gene ε4ε4 is associated with elevated risk of primary open angle glaucoma in Asians: a meta-analysis.BMC medical genetics · 2014Pooled it
- Pooled it
- Polygenic Risk Score Impact on Susceptibility to Age-Related Macular Degeneration in Polish Patients.Journal of clinical medicine · 2022Article
- Cell-Type-Specific Complement Expression in the Healthy and Diseased Retina.Cell reports · 2019Article
- Exploring the structural similarity yet functional distinction between coagulation factor XIII-B and complement factor H sushi domains.Journal of thrombosis and thrombolysis · 2019Article
- Identification of genes required for eye development by high-throughput screening of mouse knockouts.Communications biology · 2018Article
- Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine.Progress in retinal and eye research · 2017Review
- A targeted approach to genome-wide studies reveals new genetic associations with central corneal thickness.Molecular vision · 2017Article
- Tissue Specificity of Human Disease Module.Scientific reports · 2016Article
- Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma.Molecular neurodegeneration · 2016Article
- Roles of CYP2C19 Gene Polymorphisms in Susceptibility to POAG and Individual Differences in Drug Treatment Response.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Article
- Deletion of myosin VI causes slow retinal optic neuropathy and age-related macular degeneration (AMD)-relevant retinal phenotype.Cellular and molecular life sciences : CMLS · 2015Article
- Transcriptome networks in the mouse retina: An exon level BXD RI database.Molecular vision · 2015Article
- Association between p53 codon 72 (Arg72Pro) polymorphism and primary open-angle glaucoma in Iranian patients.Iranian biomedical journal · 2015Article
- Association of MYOC and APOE promoter polymorphisms and primary open-angle glaucoma: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Association between SERPING1 rs2511989 polymorphism and age-related macular degeneration: Meta-analysis.International journal of ophthalmology · 2015Article
- Genome-wide association studies: getting to pathogenesis, the role of inflammation/complement in age-related macular degeneration.Cold Spring Harbor perspectives in medicine · 2014Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
Glaucoma and age-related macular degeneration (AMD) are the two leading causes of visual loss in the United States. We utilized a novel study design to perform a genome-wide association for both primary open angle glaucoma (POAG) and AMD. This study design utilized a two-stage process for hypothesis generation and validation, in which each disease cohort was utilized as a control for the other. A total of 400 POAG patients and 400 AMD patients were ascertained and genotyped at 500,000 loci. This study identified a novel association of complement component 7 (C7) to POAG. Additionally, an association of central corneal thickness, a known risk factor for POAG, was found to be associated with ribophorin II (RPN2). Linked monogenic loci for POAG and AMD were also evaluated for evidence of association, none of which were found to be significantly associated. However, several yielded putative associations requiring validation. Our data suggest that POAG is more genetically complex than AMD, with no common risk alleles of large effect.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.