ArticleJournal of virology2013
The tobamovirus Turnip Vein Clearing Virus 30-kilodalton movement protein localizes to novel nuclear filaments to enhance virus infection.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 39 citations in OpenAlex.
- Tobacco Mosaic Virus Movement: From Capsid Disassembly to Transport Through Plasmodesmata.Viruses · 2025Review
- Cellular Partners of Tobamoviral Movement Proteins.International journal of molecular sciences · 2025Review
- PDLP5, a plasmodesmata permeability regulator, can traffic between plant cells.NPJ science of plants · 2025Article
- The roles of movement and coat proteins in the transport of tobamoviruses between plant cells.Frontiers in plant science · 2025Review
- Nuclear actin filaments - a historical perspective.Nucleus (Austin, Tex.) · 2024Review
- Confocal Microscopy Analysis of Protein Sorting to Plasmodesmata in Nicotiana benthamiana.Journal of visualized experiments : JoVE · 2024Article
- Defense Responses Induced by Viral Movement Protein and Its Nuclear Localization Modulate Virus Cell-to-Cell Transport.Plants (Basel, Switzerland) · 2024Article
- Five questions on the cell-to-cell movement ofBBA advances · 2024Article
- Facile Purification and Use of Tobamoviral Nanocarriers for Antibody-Mediated Display of a Two-Enzyme System.Viruses · 2023Article
- Controlling Pepper Mild Mottle Virus (PMMoV) Infection in Pepper Seedlings by Use of Chemically Synthetic Silver Nanoparticles.Molecules (Basel, Switzerland) · 2022Article
- Chimeric Virus Made from crTMV RNA and the Coat Protein of Potato Leafroll Virus is Targeted to the Nucleolus and Can InfectHigh-throughput · 2020Article
- A conserved motif in three viral movement proteins from different genera is required for host factor recruitment and cell-to-cell movement.Scientific reports · 2020Article
- Disrupting the Homeostasis of High Mobility Group Protein Promotes the Systemic Movement ofFrontiers in plant science · 2020Article
- Battlefield Cytoskeleton: Turning the Tide on Plant Immunity.Molecular plant-microbe interactions : MPMI · 2019Review
- Killing two birds with one stone: How do Plant Viruses Break Down Plant Defenses and Manipulate Cellular Processes to Replicate Themselves?Journal of plant biology = Singmul Hakhoe chi · 2019Review
- The Plasmodesmal Localization Signal of TMV MP Is Recognized by Plant Synaptotagmin SYTA.mBio · 2018Article
- A new toolset for protein expression and subcellular localization studies in citrus and its application toPlant methods · 2018Article
- Chimeric Virus as a Source of the Potato Leafroll Virus Antigen.Molecular biotechnology · 2017Article
- Tobamovirus 3'-Terminal Gene Overlap May be a Mechanism for within-Host Fitness Improvement.Frontiers in microbiology · 2017Article
- Tobacco mosaic virus-directed reprogramming of auxin/indole acetic acid protein transcriptional responses enhances virus phloem loading.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Plant viruses overcome the barrier of the plant cell wall by encoding cell-to-cell movement proteins (MPs), which direct newly replicated viral genomes to, and across, the wall. The paradigm for how a single MP regulates and coordinates these activities is the Tobacco mosaic virus (TMV) 30-kDa protein (MP(TMV)). Detailed studies demonstrate that TMV multiplies exclusively in the cytoplasm and have documented associations of MP(TMV) with endoplasmic reticulum (ER) membrane, microtubules, and plasmodesmata throughout the course of infection. As TMV poorly infects Arabidopsis thaliana, Turnip vein clearing virus (TVCV) is the tobamovirus of choice for studies in this model plant. A key problem, which has contributed to confusion in the field, is the unproven assumption that the TVCV and TMV life cycles are identical. We engineered an infectious TVCV replicon that expressed a functional fluorescence-tagged MP(TVCV) and report here the unexpected discovery that MP(TVCV), beyond localizing to ER membrane and plasmodesmata, targeted to the nucleus in a nuclear localization signal (NLS)-dependent manner, where it localized to novel F-actin-containing filaments that associated with chromatin. The MP(TVCV) NLS appeared to be conserved in the subgroup 3 tobamoviruses, and our mutational analyses showed that nuclear localization of MP(TVCV) was necessary for efficient TVCV cell-to-cell movement and systemic infection in Nicotiana benthamiana and Arabidopsis thaliana. Our studies identify a novel nuclear stage in TVCV infection and suggest that nuclear MP encoded by TVCV and other subgroup 3 tobamoviruses interacts with F-actin and chromatin to modulate host defenses or cellular physiology to favor virus movement and infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.