ArticleDevelopment (Cambridge, England)2013
PAR-2, LGL-1 and the CDC-42 GAP CHIN-1 act in distinct pathways to maintain polarity in the C. elegans embryo.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Asymmetric distribution of actin-related proteins in the earlybioRxiv : the preprint server for biology · 2026Article
- Oligomerization and positive feedback on membrane recruitment encode dynamically stable PAR-3 asymmetries in thebioRxiv : the preprint server for biology · 2025Article
- Balancing reaction-diffusion network for cell polarization pattern with stability and asymmetry.eLife · 2025Article
- Quantitative perturbation-phenotype maps reveal nonlinear responses underlying robustness of PAR-dependent asymmetric cell division.PLoS biology · 2024Article
- Orchestrating nonmuscle myosin II filament assembly at the onset of cytokinesis.Molecular biology of the cell · 2022Article
- Advances in the study of CDC42 in the female reproductive system.Journal of cellular and molecular medicine · 2022Review
- Single-molecule FISH inmicroPublication biology · 2022Article
- RhoGAP RGA-8 supports morphogenesis inBiology open · 2020Article
- Going with the flow: insights fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- CDC-42 Interactions with Par Proteins Are Critical for Proper Patterning in Polarization.Cells · 2020Article
- Article
- Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans.Nature communications · 2020Article
- Mechanochemical Control of Symmetry Breaking in theFrontiers in cell and developmental biology · 2020Review
- Guiding self-organized pattern formation in cell polarity establishment.Nature physics · 2019Article
- Spindle assembly checkpoint strength is linked to cell fate in the Caenorhabditis elegans embryo.Molecular biology of the cell · 2018Article
- The PAR proteins: from molecular circuits to dynamic self-stabilizing cell polarity.Development (Cambridge, England) · 2017Review
- aPKC Cycles between Functionally Distinct PAR Protein Assemblies to Drive Cell Polarity.Developmental cell · 2017Article
- PAR proteins regulate maintenance-phase myosin dynamics duringMolecular biology of the cell · 2017Article
- CYK-4 regulates Rac, but not Rho, during cytokinesis.Molecular biology of the cell · 2017Article
- Regulation of Cell Polarity by PAR-1/MARK Kinase.Current topics in developmental biology · 2017Review
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3 authors at 1 institution in 1 country.
Funding
Abstract
In the one-cell C. elegans embryo, polarity is maintained by mutual antagonism between the anterior cortical proteins PAR-3, PKC-3, PAR-6 and CDC-42, and the posterior cortical proteins PAR-2 and LGL-1 on the posterior cortex. The mechanisms by which these proteins interact to maintain polarity are incompletely understood. In this study, we investigate the interplay among PAR-2, LGL-1, myosin, the anterior PAR proteins and CDC-42. We find that PAR-2 and LGL-1 affect cortical myosin accumulation by different mechanisms. LGL-1 does not directly antagonize the accumulation of cortical myosin and instead plays a role in regulating PAR-6 levels. By contrast, PAR-2 likely has separate roles in regulating cortical myosin accumulation and preventing the expansion of the anterior cortical domain. We also provide evidence that asymmetry of active CDC-42 can be maintained independently of LGL-1 and PAR-2 by a redundant pathway that includes the CDC-42 GAP CHIN-1. Finally, we show that, in addition to its primary role in regulating the size of the anterior cortical domain via its binding to PAR-6, CDC-42 has a secondary role in regulating cortical myosin that is not dependent on PAR-6.
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