ArticleDevelopment (Cambridge, England)2013
Extramacrochaetae imposes order on the Drosophila eye by refining the activity of the Hedgehog signaling gradient.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Extramacrochaetae regulates Notch signaling in thebioRxiv : the preprint server for biology · 2024Article
- Control of fate specification within the dorsal head of Drosophila melanogaster.Development (Cambridge, England) · 2024Article
- Patterning of theFrontiers in cell and developmental biology · 2023Review
- Article
- The timing of cell fate decisions is crucial for initiating pattern formation in the Drosophila eye.Development (Cambridge, England) · 2022Article
- Eyeless/Pax6 initiates eye formation non-autonomously from the peripodial epithelium.Development (Cambridge, England) · 2018Article
- The fly eye: Through the looking glass.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- The Notch pathway regulates the Second Mitotic Wave cell cycle independently of bHLH proteins.Developmental biology · 2017Article
- FLPing Genes On and Off in Drosophila.Methods in molecular biology (Clifton, N.J.) · 2017Review
- Periodic patterning of the Drosophila eye is stabilized by the diffusible activator Scabrous.Nature communications · 2016Article
- The quest for restoring hearing: Understanding ear development more completely.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Review
- Inhibition of Daughterless by Extramacrochaetae mediates Notch-induced cell proliferation.Development (Cambridge, England) · 2015Article
- Extramacrochaetae functions in dorsal-ventral patterning of Drosophila imaginal discs.Development (Cambridge, England) · 2015Article
- Article
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2 authors.
Funding
Abstract
The compound eye of Drosophila melanogaster is configured by a differentiating wave, the morphogenetic furrow, that sweeps across the eye imaginal disc and transforms thousands of undifferentiated cells into a precisely ordered repetitive array of 800 ommatidia. The initiation of the furrow at the posterior margin of the epithelium and its subsequent movement across the eye field is controlled by the activity of the Hedgehog (Hh) signaling pathway. Differentiating photoreceptors that lie behind the furrow produce and secrete the Hh morphogen, which is captured by cells within the furrow itself. This leads to the stabilization of the full-length form of the zinc-finger transcription factor Cubitus interruptus (Ci(155)), the main effector of Hh signaling. Ci(155) functions as a transcriptional activator of a number of downstream targets, including decapentaplegic (dpp), a TGFβ homolog. In this report, we describe a mechanism that is in place within the fly retina to limit Hh pathway activity within and ahead of the furrow. We demonstrate that the helix-loop-helix (HLH) protein Extramacrochaetae (Emc) regulates Ci(155) levels. Loss of emc leads to an increase in Ci(155) levels, nuclear migration, apical cell constriction and an acceleration of the furrow. We find that these roles are distinct from the bHLH protein Hairy (H), which we show restricts atonal (ato) expression ahead of the furrow. Secondary furrow initiation along the dorsal and ventral margins is blocked by the activity of the Wingless (Wg) pathway. We also show that Emc regulates and cooperates with Wg signaling to inhibit lateral furrow initiation.
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