Evidence map›Paper›PMID 23536541›Full record

ArticleJournal of the Royal Society, Interface2013

Aminosilane functionalizations of mesoporous oxidized silicon for oligonucleotide synthesis and detection.

Luca De Stefano, Giorgia Oliviero, Jussara Amato, Nicola Borbone, Gennaro Piccialli, Luciano Mayol, Ivo Rendina, Monica Terracciano, Ilaria Rea

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Royal Society, Interface, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 69 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Luca De StefanoNational Council of Research, Institute for Microelectronics and Microsystems, Via P. Castellino 111, Naples, Italy.
Giorgia Oliviero
Jussara Amato
Nicola Borbone
Gennaro Piccialli
Luciano Mayol
Ivo Rendina
Monica Terracciano
Ilaria Rea
University of Naples Federico II · ITInstitute for Microelectronics and Microsystems · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Direct solid phase synthesis of peptides and oligonucleotides (ONs) requires high chemical stability of the support material. In this work, we have investigated the passivation ability of porous oxidized silicon multilayered structures by two aminosilane compounds, 3-aminopropyltriethoxysilane and 3-aminopropyldimethylethoxysilane (APDMES), for optical label-free ON biosensor fabrication. We have also studied by spectroscopic reflectometry the hybridization between a 13 bases ON, directly grown on the aminosilane modified porous oxidized silicon by in situ synthesis, and its complementary sequence. Even if the results show that both devices are stable to the chemicals (carbonate/methanol) used, the porous silica structure passivated by APDMES reveals higher functionalization degree due to less steric hindrance of pores.

Indexed as

Biosensing TechniquesSolid-Phase Synthesis TechniquesOligonucleotidesPorosityPropylaminesSilanesSilicon(3-aminopropyl)dimethylethoxysilaneamino-propyl-triethoxysilaneOligonucleotidesPropylaminesSilanesSilicon

Identifiers

PMID23536541
PMCPMC3645424
OpenAlexW2101699606

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.