ArticleJournal of the Royal Society, Interface2013
Fluid mechanical consequences of pendular activity, segmentation and pyloric outflow in the proximal duodenum of the rat and the guinea pig.
Article in Journal of the Royal Society, Interface, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 67 citations in OpenAlex.
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- Potential of guar gum as a leaky gut model in broilers: Digestibility, performance, and microbiota responses.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation.Scientific reports · 2024Article
- Effects of prophylactic antibiotics administration on barrier properties of intestinal mucosa and mucus from preterm born piglets.Drug delivery and translational research · 2023Article
- Predicting the viscosity of digesta from the physical characteristics of particle suspensions using existing rheological models.Journal of the Royal Society, Interface · 2018Article
- Quantifying Patterns of Smooth Muscle Motility in the Gut and Other Organs With New Techniques of Video Spatiotemporal Mapping.Frontiers in physiology · 2018Article
- A Multiphase Flow in the Antroduodenal Portion of the Gastrointestinal Tract: A Mathematical Model.Computational and mathematical methods in medicine · 2016Article
- A review of mixing and propulsion of chyme in the small intestine: fresh insights from new methods.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Review
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- Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted numerical experiments to study the influence of non-propagating longitudinal and circular contractions, i.e. pendular activity and segmentation, respectively, on flow and mixing in the proximal duodenum. A lattice-Boltzmann numerical method was developed to simulate the fluid mechanical consequences for each of 22 randomly selected sequences of high-definition video of real longitudinal and radial contractile activity in the isolated proximal duodenum of the rat and guinea pig. During pendular activity in the rat duodenum, the flow was characterized by regions of high shear rate. Mixing was so governed by shearing deformation of the fluid that increased the interface between adjacent domains and accelerated their inter-diffusion (for diffusion coefficients approx. less than 10(-8) m² s(-1)). When pendular activity was associated with a slow gastric outflow characteristic of post-prandial period, the dispersion was also improved, especially near the walls. Mixing was not promoted by isolated segmentative contractions in the guinea pig duodenum and not notably influenced by pylorus outflow. We concluded that pendular activity generates mixing of viscous fluids 'in situ' and accelerates the diffusive mass transfer, whereas segmentation may be more important in mixing particulate suspensions with high solid volume ratios.
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