Evidence map›Paper›PMID 23536417›Full record

Trial reportMovement disorders : official journal of the Movement Disorder Society2013

A two-year randomized controlled trial of progressive resistance exercise for Parkinson's disease.

Daniel M Corcos, Julie A Robichaud, Fabian J David, Sue E Leurgans, David E Vaillancourt, Cynthia Poon, Miriam R Rafferty, Wendy M Kohrt, Cynthia L Comella

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Movement disorders : official journal of the Movement Disorder Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 145 papers, 29 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed, 29 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03517371 nacompletednot on this mapstarted 2019, after this paper: background citation

Walking and mHealth to Increase Participation in Parkinson Disease

TypeinterventionalSponsorBoston University Charles River CampusRan2019 to 2024Enrolled140ConditionsParkinson DiseaseArmsmHealth delivered exercise program, Exercise only
NCT06246747 nacompletednot on this mapstarted 2020, after this paper: background citation

The Use of Telerehabilitation to Improve Movement-related Outcomes and Quality of Life for Patients With Parkinson's Disease: A Pilot Randomized Controlled Trial

TypeinterventionalSponsorWizecareRan2020 to 2023Enrolled19ConditionsParkinson DiseaseArmsIn clinic physical therapy, Telerehabilitation only
NCT06893055 narecruitingnot on this mapstarted 2025, after this paper: background citation

Strength-Endurance Circuit Training in Parkinson's Disease: Effects on Disease Severity, Physical Performance, Blood Biomarkers and Quality of Life.

TypeinterventionalSponsorGeneral University Hospital, PragueRan2025 to 2027Enrolled90ConditionsParkinson Disease, IdiopathicArmsStrength-Endurance Training, Endurance Training
3 · Its place in the literature

Who cites it

145 citing papers in PubMed, 29 syntheses or guidelines pooled it.

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85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Daniel M CorcosDepartment of Kinesiology and Nutrition, University of Illinois, Chicago, IL, USA. dcorcos@uic.edu
Julie A Robichaud
Fabian J David
Sue E Leurgans
David E Vaillancourt
Cynthia Poon
Miriam R Rafferty
Wendy M Kohrt
Cynthia L Comella

Funding

MOTOR DEFICITS--EXPERIMENTAL AND CLINICAL CORRELATESR01NS028127 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CORCOS, DANIEL M. · 1993 to 2011
$4.0M
NINDS NIH HHS R01 NS028127NINDS NIH HHS R01-NS28127-12NINDS NIH HHS R01-NS28127-13NINDS NIH HHS R01-NS28127-14NINDS NIH HHS R01-NS28127-15NINDS NIH HHS R01-NS28127-16
6 · The paper itself

Abstract

The effects of progressive resistance exercise (PRE) on the motor signs of Parkinson's disease have not been studied in controlled trials. The objective of the current trial was to compare 6-, 12-, 18-, and 24-month outcomes of patients with Parkinson's disease who received PRE with a stretching, balance, and strengthening exercise program. The authors conducted a randomized controlled trial between September 2007 and July 2011. Pairs of patients matched by sex and off-medication scores on the Unified Parkinson's Disease Rating Scale, motor subscale (UPDRS-III), were randomly assigned to the interventions with a 1:1 allocation ratio. The PRE group performed a weight-lifting program. The modified fitness counts (mFC) group performed a stretching, balance, and strengthening exercise program. Patients exercised 2 days per week for 24 months at a gym. A personal trainer directed both weekly sessions for the first 6 months and 1 weekly session after 6 months. The primary outcome was the off-medication UPDRS-III score. Patients were followed for 24 months at 6-month intervals. Of 51 patients, 20 in the PRE group and 18 in the mFC group completed the trial. At 24 months, the mean off-medication UPDRS-III score decreased more with PRE than with mFC (mean difference, -7.3 points; 95% confidence interval, -11.3 to -3.6; P<0.001). The PRE group had 10 adverse events, and the mFC group had 7 adverse events. PRE demonstrated a statistically and clinically significant reduction in UPDRS-III scores compared with mFC and is recommended as a useful adjunct therapy to improve Parkinsonian motor signs. © 2013 Movement Disorder Society.

Indexed as

AgedDouble-Blind MethodExercise TherapyFemaleHumansLongitudinal StudiesMaleMiddle AgedMotor ActivityMovementMuscle StrengthOutcome Assessment, Health CareParkinson DiseaseQuality of LifeRetrospective StudiesSeverity of Illness IndexParkinson's diseaseprogressive resistance exerciserandomized controlled trialstrength trainingUnified Parkinson's Disease Rating Scale motor subscale

Identifiers

PMID23536417
PMCPMC3701730

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.