ReviewDevelopmental neurobiology2014
Therapeutic approaches for shankopathies.
Review in Developmental neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Autism patient-derived SHANK2BMolecular psychiatry · 2024Article
- Targeting Shank3 deficiency and paresthesia in autism spectrum disorder: A brief review.Frontiers in molecular neuroscience · 2023Review
- Review
- Imbalanced post- and extrasynaptic SHANK2A functions during development affect social behavior in SHANK2-mediated neuropsychiatric disorders.Molecular psychiatry · 2021Article
- Autism-associatedeLife · 2021Article
- Social Deficits and Repetitive Behaviors Are Improved by Early Postnatal Low-Dose VPA Intervention in a NovelFrontiers in neuroscience · 2021Article
- Somatic structural variation targets neurodevelopmental genes and identifiesGenome research · 2020Article
- Article
- Eighteen-year-old man with autism, obsessive compulsive disorder and aBMJ case reports · 2018Article
- Cell-Type-SpecificThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons.Neuron · 2016Article
- Lithium as a rescue therapy for regression and catatonia features in two SHANK3 patients with autism spectrum disorder: case reports.BMC psychiatry · 2015Article
- Novel Therapeutic Approach for Autism Spectrum Disorder: Focus on SHANK3.Current neuropharmacology · 2015Review
- Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit.Frontiers in cellular neuroscience · 2015Article
- Whole genome sequencing reveals a de novo SHANK3 mutation in familial autism spectrum disorder.PloS one · 2015Article
- Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism.Neuroscience and biobehavioral reviews · 2014Review
- Molecular handoffs in nitrergic neurotransmission.Frontiers in medicine · 2014Review
- Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice.Molecular autism · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Despite recent advances in understanding the molecular mechanisms of autism spectrum disorders (ASD), the current treatments for these disorders are mostly focused on behavioral and educational approaches. The considerable clinical and molecular heterogeneity of ASD present a significant challenge to the development of an effective treatment targeting underlying molecular defects. Deficiency of SHANK family genes causing ASD represent an exciting opportunity for developing molecular therapies because of strong genetic evidence for SHANK as causative genes in ASD and the availability of a panel of Shank mutant mouse models. In this article, we review the literature suggesting the potential for developing therapies based on molecular characteristics and discuss several exciting themes that are emerging from studying Shank mutant mice at the molecular level and in terms of synaptic function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.