ArticleJournal of assisted reproduction and genetics2013
Association study between FSHR Ala307Thr and Ser680Asn variants and polycystic ovary syndrome (PCOS) in Northern Chinese Han women.
Article in Journal of assisted reproduction and genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Polymorphisms in FSHR modulating susceptibility to polycystic ovary syndrome: an updated meta-analysis.Journal of ovarian research · 2023Pooled it
- Association of FSHR and DENND1A polymorphisms with polycystic ovary syndrome: a meta-analysis.JBRA assisted reproduction · 2023Pooled it
- Significance of Follicle-Stimulating Hormone Receptor Gene Single-Nucleotide Polymorphism rs6165/rs6166 Analysis for Infertility-Associated Ovarian Disease Susceptibility Prediction and Optimized Individualized Ovulation Induction/Ovarian Stimulation.Diagnostics (Basel, Switzerland) · 2026Review
- Metformin-Driven Activation of Polymorphic Follicle-Stimulating Hormone Receptors for Polycystic Ovary Syndrome Treatment: A Computational Study.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Follicle Stimulating Hormone Receptor (FSHR) Polymorphisms and Polycystic Ovary Syndrome (PCOS).Frontiers in endocrinology · 2019Review
- Potential genetic polymorphisms predicting polycystic ovary syndrome.Endocrine connections · 2018Review
- Identification of selected genetic polymorphisms in polycystic ovary syndrome in Sri Lankan women using low cost genotyping techniques.PloS one · 2018Article
- FSH receptor gene p. Thr307Ala and p. Asn680Ser polymorphisms are associated with the risk of polycystic ovary syndrome.Journal of assisted reproduction and genetics · 2017Article
- Family-based analysis of eight susceptibility loci in polycystic ovary syndrome.Scientific reports · 2015Article
- Han Chinese polycystic ovary syndrome risk variants in women of European ancestry: relationship to FSH levels and glucose tolerance.Human reproduction (Oxford, England) · 2015Article
- Assessment of FSHR, AMH, and AMHRII variants in women with polycystic ovary syndrome.Endocrine · 2015Article
- Leutinizing hormone/choriogonadotropin receptor and follicle stimulating hormone receptor gene variants in polycystic ovary syndrome.Journal of assisted reproduction and genetics · 2015Article
- Functional genomics of PCOS: from GWAS to molecular mechanisms.Trends in endocrinology and metabolism: TEM · 2015Review
- Association between FSHR polymorphisms and polycystic ovary syndrome among Chinese women in north China.Journal of assisted reproduction and genetics · 2014Article
- New insights into the genetic basis of infertility.The application of clinical genetics · 2014Review
- Structural Changes in the Medial Prefrontal Cortex and Anterior Cingulate Cortex of Dehydroepiandrosterone-Induced Wistar Rat Model of Polycystic Ovarian Syndrome.Basic and clinical neuroscienceArticle
- An update on polycystic ovary syndrome: A review of the current state of knowledge in diagnosis, genetic etiology, and emerging treatment options.Women's health (London, England)Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolycystic ovary syndrome (PCOS) is a common complex genetic endocrinopathy. It has high heritability, and twin studies indicate that it is a complex polygenic disorder. Searching for major genes of PCOS is crucial to clarify its molecular pathogenesis. A previous genome-wide association study in Chinese women with PCOS identified a region on chromosome 2p16.3 that encodes the follicle-stimulating hormone receptor (FSHR) genes as a reproducible PCOS susceptibility locus. In the present study, we performed a replication analysis of the association between two common variants of the FSHR gene and PCOS in Northern Chinese Han women.
resultsWe recruited 384 unrelated PCOS patients and 768 healthy individuals from the Shaanxi province in the northern part of China. Two polymorphisms (Ala307Thr and Ser680Asn) of the FSHR gene and the clinical characteristics of the study subjects were analyzed in the case-control sample. The frequency of FSHR Ala307Thr and Ser680Asn variants along with the haplotype was not significantly different between the PCOS patients and the controls; however, the Ser680 variants may be associated with high levels of FSH and low E2 levels.
conclusionThe variant of Ser680 was not associated with PCOS but it may be related to high FSH levels. The present study suggests that the two variants of the FSHR gene are not a causative factor of PCOS in Northern Chinese Han women.
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