ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Retinoic acid deficiency impairs the vestibular function.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Activity and retinoic acid drive hair cell spatial patterning in the zebrafish utricle.Development (Cambridge, England) · 2026Article
- Timeline of Developmental Defects Generated upon Genetic Inhibition of the Retinoic Acid Receptor Signaling Pathway.Biomedicines · 2023Article
- Implication of Vestibular Hair Cell Loss of Planar Polarity for the Canal and Otolith-Dependent Vestibulo-Ocular Reflexes inFrontiers in neuroscience · 2021Article
- Surgical techniques and functional evaluation for vestibular lesions in the mouse: unilateral labyrinthectomy (UL) and unilateral vestibular neurectomy (UVN).Journal of neurology · 2020Article
- Retinoic acid synthesis and autoregulation mediate zonal patterning of vestibular organs and inner ear morphogenesis.Development (Cambridge, England) · 2020Article
- Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations.Nature communications · 2020Article
- Morphological and functional correlates of vestibular synaptic deafferentation and repair in a mouse model of acute-onset vertigo.Disease models & mechanisms · 2019Article
- cVEMP correlated with imbalance in a mouse model of vestibular disorder.Environmental health and preventive medicine · 2019Article
- Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and necessary for auditory and equilibrium function.Scientific reports · 2018Article
- Retinoic acid signaling and neurogenic niche regulation in the developing peripheral nervous system of the cephalochordate amphioxus.Cellular and molecular life sciences : CMLS · 2018Article
- Roles of Retinoic Acid Signaling in Shaping the Neuronal Architecture of the Developing Amphioxus Nervous System.Molecular neurobiology · 2018Article
- CHD7 represses the retinoic acid synthesis enzyme ALDH1A3 during inner ear development.JCI insight · 2018Article
- No Gain No Pain: Relations Between Vestibulo-Ocular Reflexes and Motion Sickness in Mice.Frontiers in neurology · 2018Article
- Local gene therapy durably restores vestibular function in a mouse model of Usher syndrome type 1G.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Alternative Biotransformation of Retinal to Retinoic Acid or Retinol by an Aldehyde Dehydrogenase from Bacillus cereus.Applied and environmental microbiology · 2016Article
- Congenital vestibular disease in captive Sumatran tigers (Panthera tigris ssp. sumatrae) in Australasia.Veterinary journal (London, England : 1997) · 2015Article
- Preserved otolith organ function in caspase-3-deficient mice with impaired horizontal semicircular canal function.Experimental brain research · 2015Article
- Dynamic characteristics of otolith ocular response during counter rotation about dual yaw axes in mice.Neuroscience · 2015Article
- CHD7 and retinoic acid signaling cooperate to regulate neural stem cell and inner ear development in mouse models of CHARGE syndrome.Human molecular genetics · 2014Article
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Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The retinaldehyde dehydrogenase 3 (Raldh3) gene encodes a major retinoic acid synthesizing enzyme and is highly expressed in the inner ear during embryogenesis. We found that mice deficient in Raldh3 bear severe impairment in vestibular functions. These mutant mice exhibited spontaneous circling/tilted behaviors and performed poorly in several vestibular-motor function tests. In addition, video-oculography revealed a complete loss of the maculo-ocular reflex and a significant reduction in the horizontal angular vestibulo-ocular reflex, indicating that detection of both linear acceleration and angular rotation were compromised in the mutants. Consistent with these behavioral and functional deficiencies, morphological anomalies, characterized by a smaller vestibular organ with thinner semicircular canals and a significant reduction in the number of otoconia in the saccule and the utricle, were consistently observed in the Raldh3 mutants. The loss of otoconia in the mutants may be attributed, at least in part, to significantly reduced expression of Otop1, which encodes a protein known to be involved in calcium regulation in the otolithic organs. Our data thus reveal a previously unrecognized role of Raldh3 in structural and functional development of the vestibular end organs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.