ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Engineered deafness reveals that mouse courtship vocalizations do not require auditory experience.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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Who cites it
90 citing papers in PubMed, 134 citations in OpenAlex.
- Vocal and social impairments in songbirds embryonically exposed to an autism risk factor.iScience · 2026Article
- Generation of marmoset monkeys with a non-mosaic disruption of the OTOF gene as a model of human deafness.Nature communications · 2026Article
- Auditory cortex modulates call duration in rats.Communications biology · 2026Article
- Rates of female mouse ultrasonic vocalizations are low and are not modulated by estrous state during interactions with muted males.Scientific reports · 2025Article
- Vocal recognition of partners by female prairie voles.iScience · 2025Article
- California mice (Peromyscus californicus) adjust mouth movements for vocal production during early postnatal development.BMC biology · 2024Article
- Article
- Vocal recognition of partners by female prairie voles.bioRxiv : the preprint server for biology · 2024Article
- Humans need auditory experience to produce typical volitional nonverbal vocalizations.Communications psychology · 2024Article
- Nestin-expressing cells are mitotically active in the mammalian inner ear.Hearing research · 2024Article
- Selectivity to acoustic features of human speech in the auditory cortex of the mouse.Hearing research · 2024Article
- Ultrasonic vocalization phenotypes in the Ts65Dn and Dp(16)1Yey mouse models of Down syndrome.Physiology & behavior · 2023Article
- Predictive Mouse Ultrasonic Vocalization Sequences: Uncovering Behavioral Significance, Auditory Cortex Neuronal Preferences, and Social-Experience-Driven Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Rodent ultrasonic vocal interaction resolved with millimeter precision using hybrid beamforming.eLife · 2023Article
- Bats possess the anatomical substrate for a laryngeal motor cortex.bioRxiv : the preprint server for biology · 2023Article
- Temporal dynamics of isolation calls emitted by pups in environmental and genetic mouse models of autism spectrum disorder.Frontiers in neuroscience · 2023Article
- Peripheral Fragile X messenger ribonucleoprotein is required for the timely closure of a critical period for neuronal susceptibility in the ventral cochlear nucleus.Frontiers in cellular neuroscience · 2023Article
- Gestational hypoxia in late pregnancy differentially programs subcortical brain maturation in male and female rat offspring.Biology of sex differences · 2022Article
- Effects of Congenital Blindness on Ultrasonic Vocalizations and Social Behaviors in the ZRDBA Mouse.Frontiers in behavioral neuroscience · 2022Article
- Ultrasonic Vocalizations in Adult C57BL/6J Mice: The Role of Sex Differences and Repeated Testing.Frontiers in behavioral neuroscience · 2022Article
30 more citing papers are in PubMed but not listed here.
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5 authors at 2 institutions in 1 country.
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Abstract
Auditory experience during development is necessary for normal language acquisition in humans. Although songbirds, some cetaceans, and maybe bats may also be vocal learners, vocal learning has yet to be well established for a laboratory mammal. Mice are potentially an excellent model organism for studying mechanisms underlying vocal communication. Mice vocalize in different social contexts, yet whether they learn their vocalizations remains unresolved. To address this question, we compared ultrasonic courtship vocalizations emitted by chronically deaf and normal hearing adult male mice. We deafened CBA/CaJ male mice, engineered to express diphtheria toxin (DT) receptors in hair cells, by systemic injection of DT at postnatal day 2 (P2). By P9, almost all inner hair cells were absent and by P16 all inner and outer hair cells were absent in DTR mice. These mice did not show any auditory brainstem responses as adults. Wild-type littermates, also treated with DT at P2, had normal hair cells and normal auditory brainstem responses. We compared the temporal structure of vocalization bouts, the types of vocalizations, the patterns of syllables, and the acoustic features of each syllable type emitted by hearing and deaf males in the presence of a female. We found that almost all of the vocalization features we examined were similar in hearing and deaf animals. These findings indicate that mice do not need auditory experience during development to produce normal ultrasonic vocalizations in adulthood. We conclude that mouse courtship vocalizations are not acquired through auditory feedback-dependent learning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.