ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Learning increases intrinsic excitability of hippocampal interneurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 75 citations in OpenAlex.
- Instrumental learning enhances the intrinsic excitability of basal amygdala projection neurons.Learning & memory (Cold Spring Harbor, N.Y.) · 2026Article
- Conditioning and pseudoconditioning differently change intrinsic excitability of inhibitory interneurons in the neocortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Synaptic configuration and reconfiguration in the neocortex are spatiotemporally selective.Anatomical science international · 2024Review
- BK channels sustain neuronal CaCellular and molecular life sciences : CMLS · 2023Article
- Hippocampal GABAergic interneurons and memory.Neuron · 2023Review
- mTORC1-mediated acquisition of reward-related representations by hippocampal somatostatin interneurons.Molecular brain · 2023Article
- Sustained Activity of Hippocampal Parvalbumin-Expressing Interneurons Supports Trace Eyeblink Conditioning in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Learning-related changes in cellular activity within mouse dentate gyrus during trace eyeblink conditioning.Hippocampus · 2022Article
- Long-term potentiation at pyramidal cell to somatostatin interneuron synapses controls hippocampal network plasticity and memory.iScience · 2022Article
- Somatostatin and Somatostatin-Containing Interneurons-From Plasticity to Pathology.Biomolecules · 2022Review
- Endocannabinoids Tune Intrinsic Excitability in O-LM Interneurons by Direct Modulation of Postsynaptic Kv7 Channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Hippocampal Interneurons are Required for Trace Eyeblink Conditioning in Mice.Neuroscience bulletin · 2021Article
- The Engram's Dark Horse: How Interneurons Regulate State-Dependent Memory Processing and Plasticity.Frontiers in neural circuits · 2021Review
- Hyperexcitable Parvalbumin Interneurons Render Hippocampal Circuitry Vulnerable to Amyloid Beta.iScience · 2020Article
- Article
- Intrinsic Excitability Increase in Cerebellar Purkinje Cells after Delay Eye-Blink Conditioning in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- A Cellular Mechanism of Learning-Induced Enhancement of Synaptic Inhibition: PKC-Dependent Upregulation of KCC2 Activation.Scientific reports · 2020Article
- The Emergence of a Stable Neuronal Ensemble from a Wider Pool of Activated Neurons in the Dorsal Medial Prefrontal Cortex during Appetitive Learning in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Learning and aging affect neuronal excitability and learning.Neurobiology of learning and memory · 2020Review
- Somatostatin receptors (SSTR1-5) on inhibitory interneurons in the barrel cortex.Brain structure & function · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Learning-related intrinsic excitability changes of pyramidal neurons via modulation of the postburst afterhyperpolarization (AHP) have been repeatedly demonstrated in multiple brain regions (especially the hippocampus), after a variety of learning tasks, and in multiple species. While exciting and important, the changes in pyramidal neurons are only a part of the neural circuitry involved in successful learning. For a more complete picture of the dynamic learning-related changes in the neural network, changes in inhibitory circuitry must also be systematically examined and characterized. Here we show in young adult rats and mice that learning the hippocampus-dependent trace eyeblink conditioning task induces enhanced inhibition onto CA1 pyramidal neurons mediated, in part, by an increase in intrinsic excitability of somatostatin-positive inhibitory neurons (SOMs). Furthermore, both CA1 pyramidal and SOM interneurons shared a common cellular mechanism (reduction in SK channel-mediated AHP) that led to the learning-induced increased intrinsic excitability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.