ArticleGenes and immunity2013
Intrinsic bias and public rearrangements in the human immunoglobulin Vλ light chain repertoire.
Article in Genes and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Single-cell analysis of cerebrospinal fluid reveals common features of neuroinflammation.Cell reports. Medicine · 2025Article
- Comprehensive characterization and database construction of immune repertoire in the largest Chinese glioma cohort.iScience · 2024Article
- Complete variable domain sequences of monoclonal antibody light chains identified from untargeted RNA sequencing data.Frontiers in immunology · 2023Article
- A BALB/c IGHV Reference Set, Defined by Haplotype Analysis of Long-Read VDJ-C Sequences From F1 (BALB/c x C57BL/6) Mice.Frontiers in immunology · 2022Article
- Lower Somatic Mutation Levels in theEvidence-based complementary and alternative medicine : eCAM · 2021Article
- How repertoire data are changing antibody science.The Journal of biological chemistry · 2020Review
- High Frequency of Shared Clonotypes in Human T Cell Receptor Repertoires.Cell reports · 2020Article
- Deep Characterization of the Human Antibody Response to Natural Infection Using Longitudinal Immune Repertoire Sequencing.Molecular & cellular proteomics : MCP · 2020Article
- Message from the new Editors-in-Chief.Genes and immunity · 2019Article
- The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen.Science translational medicine · 2018Article
- On being the right size: antibody repertoire formation in the mouse and human.Immunogenetics · 2018Review
- Immunoglobulin Light Chain Gene Rearrangements, Receptor Editing and the Development of a Self-Tolerant Antibody Repertoire.Frontiers in immunology · 2018Review
- Evidence for Shaping of Light Chain Repertoire by Structural Selection.Frontiers in immunology · 2018Article
- Structurally Mapping Antibody Repertoires.Frontiers in immunology · 2018Article
- Reliability of immune receptor rearrangements as genetic markers for minimal residual disease monitoring.Bone marrow transplantation · 2016Article
- Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- B-cell repertoire responses to varicella-zoster vaccination in human identical twins.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire.Nature medicine · 2015Article
- The promise and challenge of high-throughput sequencing of the antibody repertoire.Nature biotechnology · 2014Review
- The application of next generation sequencing to the understanding of antibody repertoires.Frontiers in immunology · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immunoglobulin lambda (IGL) repertoires from two unrelated human blood samples, three NOD-scid-IL2Rγ(null) mice engrafted with human hematopoietic stem cells and two pairs of monozygotic twin blood samples were determined by Roche 454 sequencing to generate a total of about 700 000 IGL sequences. We applied bioinformatic analysis to examine IGL repertoires wherein, surprisingly, 20% of CDR-L3 peptide sequences were 'public' (shared across individuals); moreover, full-length IGL protein sequences (VJ recombinants) were also present in the public domain. Subtle yet significant differences in CDR-L3 nontemplated nucleotide addition, IGL V-gene family usage, and amino-acid composition distinguished the public CDR-L3 groups from the private groups. These data suggest that public CDR-L3 intervals can arise by intrinsic genetic mechanisms irrespective of different B-cell developmental milieu (human versus humanized mouse). Furthermore, the occurrence of identical public IGL protein sequences indirectly suggest the positive selection (evolutionary, somatic or both) of particular IGL chains independent of the immunoglobulin heavy chain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.