ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
Effects of repeated stress on excitatory drive of basal amygdala neurons in vivo.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 72 citations in OpenAlex.
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- Bullying Victimization and Brain Development: A Longitudinal Structural Magnetic Resonance Imaging Study from Adolescence to Early Adulthood.bioRxiv : the preprint server for biology · 2026Article
- Altered theta oscillations in basolateral amygdala and ventral hippocampus related to social defeat.BMC neuroscience · 2025Article
- SNX27: A trans-species cognitive modulator with implications for anxiety and stress susceptibility.Neurobiology of stress · 2024Article
- Characterization of Anxiety-Like Behaviors and Neural Circuitry following Chronic Moderate Noise Exposure in Mice.Environmental health perspectives · 2023Article
- Stress, associative learning, and decision-making.Neurobiology of learning and memory · 2023Review
- Specifying the Efficacy of Digital Therapeutic Tools for Depression and Anxiety: Retrospective, 2-Cohort, Real-World Analysis.Journal of medical Internet research · 2023Article
- Riluzole prevents stress-induced spine plasticity in the hippocampus but mimics it in the amygdala.Neurobiology of stress · 2022Article
- Neurobiology of Depression: Chronic Stress Alters the Glutamatergic System in the Brain-Focusing on AMPA Receptor.Biomedicines · 2022Review
- Rodent models of stress and dendritic plasticity - Implications for psychopathology.Neurobiology of stress · 2022Article
- Association of Increased Amygdala Activity with Stress-Induced Anxiety but not Social Avoidance Behavior in Mice.Neuroscience bulletin · 2022Article
- Contribution of AMPA Receptor-Mediated LTD in LA/BLA-CeA Pathway to Comorbid Aversive and Depressive Symptoms in Neuropathic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Maturation of amygdala inputs regulate shifts in social and fear behaviors: A substrate for developmental effects of stress.Neuroscience and biobehavioral reviews · 2021Review
- Sex differences in the delayed impact of acute stress on the amygdala.Neurobiology of stress · 2021Article
- Cocaine and chronic stress exposure produce an additive increase in neuronal activity in the basolateral amygdala.Addiction biology · 2021Article
- Impact of Early Life Stress on Reward Circuit Function and Regulation.Frontiers in psychiatry · 2021Review
- Amygdala Allostasis and Early Life Adversity: Considering Excitotoxicity and Inescapability in the Sequelae of Stress.Frontiers in human neuroscience · 2021Article
- Imipramine Ameliorates Depressive Symptoms by Blocking Differential Alteration of Dendritic Spine Structure in Amygdala and Prefrontal Cortex of Chronic Stress-Induced Mice.Biomolecules & therapeutics · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Chronic stress leads to heightened affective behaviors, and can precipitate the emergence of depression and anxiety. These disorders are associated with increased amygdala activity. In animal models, chronic stress leads to increased amygdala-dependent behaviors, as well as hyperactivity of amygdala neurons. However, it is not known whether increased excitatory synaptic drive after chronic stress contributes to hyperactivity of basolateral amygdala (BLA; comprised of basal, lateral, and accessory basal nuclei) neurons. This study tested whether repeated stress causes an increase in excitatory drive of basal amygdala (BA) neurons in vivo, and whether this is correlated with an increase in the number of dendritic spines and a shift in dendritic distribution. Using in vivo intracellular recordings, this study found that repeated restraint stress caused an increase in the frequency of spontaneous excitatory synaptic events in vivo, which correlated with the number of dendritic spines in reconstructed neurons. Furthermore, parallel changes in the kinetics of the synaptic events and the distribution of spines indicated a more prominent functional contribution of synaptic inputs from across the dendritic tree. The shift in spine distribution across the dendritic tree was further confirmed with the examination of Golgi-stained tissue. This abnormal physiological drive of BA neurons after repeated stress may contribute to heightened affective responses after chronic stress. A reduction in the impact of excitatory drive in the BA may therefore be a potential treatment for the harmful effects of chronic stress in psychiatric disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.