ArticleScientific reports2013
Inorganic coatings for optimized non-viral transfection of stem cells.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Gene-activation of surface-modified 3D printed calcium phosphate scaffolds.BMC chemistry · 2025Article
- Optimized biomimetic minerals maintain activity of mRNA complexes after long term storage.Acta biomaterialia · 2024Article
- Mineral coated microparticles doped with fluoride and complexed with mRNA prolong transfection in fracture healing.Frontiers in bioengineering and biotechnology · 2023Article
- A Localized Materials-Based Strategy to Non-Virally Deliver Chondroitinase ABC mRNA Improves Hindlimb Function in a Rat Spinal Cord Injury Model.Advanced healthcare materials · 2022Article
- Sustained release and protein stabilization reduce the growth factor dosage required for human pluripotent stem cell expansion.Biomaterials · 2020Article
- Single-dose mRNA therapy via biomaterial-mediated sequestration of overexpressed proteins.Science advances · 2020Article
- Mineral-Coated Microparticles Enhance mRNA-Based Transfection of Human Bone Marrow Cells.Molecular therapy. Nucleic acids · 2019Article
- A microparticle approach for non-viral gene delivery within 3D human mesenchymal stromal cell aggregates.Acta biomaterialia · 2019Article
- Dual non-viral gene delivery from microparticles within 3D high-density stem cell constructs for enhanced bone tissue engineering.Biomaterials · 2018Article
- In Vitro Bioactivity of One- and Two-Dimensional Nanoparticle-Incorporated Bone Tissue Engineering Scaffolds.Tissue engineering. Part A · 2018Article
- Non-viral gene delivery systems for tissue repair and regeneration.Journal of translational medicine · 2018Review
- MgJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2017Article
- Functionalization of microparticles with mineral coatings enhances non-viral transfection of primary human cells.Scientific reports · 2017Article
- Biomimetic Mineralization of Biomaterials Using Simulated Body Fluids for Bone Tissue Engineering and Regenerative Medicine<sup/>.Tissue engineering. Part A · 2017Review
- Nanostructured Mineral Coatings Stabilize Proteins for Therapeutic Delivery.Advanced materials (Deerfield Beach, Fla.) · 2017Article
- Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material.Scientific reports · 2017Article
- Chemical and physical properties of carbonated hydroxyapatite affect breast cancer cell behavior.Acta biomaterialia · 2015Article
- Ca-mediated electroformation of cell-sized lipid vesicles.Scientific reports · 2015Article
- How does the pathophysiological context influence delivery of bone growth factors?Advanced drug delivery reviews · 2015Review
- 3-D Scaffold Platform for Optimized Non-viral Transfection of Multipotent Stem Cells.Journal of materials chemistry. B · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
"Biomimetic" approaches for heterogeneous growth of inorganic coatings have become particularly widespread in biomedical applications, where calcium phosphate (CaP) mineral coatings are used to improve biomedical implants. Changes in coating properties can influence the effects of mineral coatings on adjacent cells, but to date it has not been practical to systematically vary inorganic coating properties to optimize specific cell behaviors. Here, we present an approach to grow CaP mineral coatings in an enhanced throughput format to identify unprecedented capabilities in non-viral gene delivery. Subtle changes in coating properties resulted in widely variable transfection, and optimized coatings led to greater than 10-fold increases in transgene expression by multiple target cell types when compared to standard techniques. The enhanced transfection observed here is substrate-mediated, and related to the characteristics of the local environment near the surface of dissolving mineral coatings. These findings may be particularly translatable to medical device applications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.