Evidence map›Paper›PMID 23535729›Full record

ArticleNature genetics2013

Large-scale genotyping identifies 41 new loci associated with breast cancer risk.

Kyriaki Michailidou, Per Hall, Anna Gonzalez-Neira, Maya Ghoussaini, Joe Dennis, Roger L Milne, Marjanka K Schmidt, Jenny Chang-Claude, Stig E Bojesen, Manjeet K Bolla and 214 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 715 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
715citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

715 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  7. Association ofJCO global oncology · 2022
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  17. Characterization of Genetic Etiologic Factors for Pediatric Acute Lymphoblastic Leukemia in Large Childhood Cancer Survivorship Cohorts.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article
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655 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

224 authors.

Kyriaki MichailidouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Per Hall
Anna Gonzalez-Neira
Maya Ghoussaini
Joe Dennis
Roger L Milne
Marjanka K Schmidt
Jenny Chang-Claude
Stig E Bojesen
Manjeet K Bolla
Qin Wang
Ed Dicks
Andrew Lee
Clare Turnbull
Nazneen Rahman
Breast and Ovarian Cancer Susceptibility Collaboration
Olivia Fletcher
Julian Peto
Lorna Gibson
Isabel Dos Santos Silva
Heli Nevanlinna
Taru A Muranen
Kristiina Aittomäki
Carl Blomqvist
Kamila Czene
Astrid Irwanto
Jianjun Liu
Quinten Waisfisz
Hanne Meijers-Heijboer
Muriel Adank
Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON)
Rob B van der Luijt
Rebecca Hein
Norbert Dahmen
Lars Beckman
Alfons Meindl
Rita K Schmutzler
Bertram Müller-Myhsok
Peter Lichtner
John L Hopper
Melissa C Southey
Enes Makalic
Daniel F Schmidt
Andre G Uitterlinden
Albert Hofman
David J Hunter
Stephen J Chanock
Daniel Vincent
François Bacot
Daniel C Tessier
Sander Canisius
Lodewyk F A Wessels
Christopher A Haiman
Mitul Shah
Robert Luben
Judith Brown
Craig Luccarini
Nils Schoof
Keith Humphreys
Jingmei Li
Børge G Nordestgaard
Sune F Nielsen
Henrik Flyger
Fergus J Couch
Xianshu Wang
Celine Vachon
Kristen N Stevens
Diether Lambrechts
Matthieu Moisse
Robert Paridaens
Marie-Rose Christiaens
Anja Rudolph
Stefan Nickels
Dieter Flesch-Janys
Nichola Johnson
Zoe Aitken
Kirsimari Aaltonen
Tuomas Heikkinen
Annegien Broeks
Laura J Van't Veer
C Ellen van der Schoot
Pascal Guénel
Thérèse Truong
Pierre Laurent-Puig
Florence Menegaux
Frederik Marme
Andreas Schneeweiss
Christof Sohn
Barbara Burwinkel
M Pilar Zamora
Jose Ignacio Arias Perez
Guillermo Pita
M Rosario Alonso
Angela Cox
Ian W Brock
Simon S Cross
Malcolm W R Reed
Elinor J Sawyer
Ian Tomlinson
Michael J Kerin
Nicola Miller
Brian E Henderson
Fredrick Schumacher
Loic Le Marchand
Irene L Andrulis
Julia A Knight
Gord Glendon
Anna Marie Mulligan
kConFab Investigators
Australian Ovarian Cancer Study Group
Annika Lindblom
Sara Margolin
Maartje J Hooning
Antoinette Hollestelle
Ans M W van den Ouweland
Agnes Jager
Quang M Bui
Jennifer Stone
Gillian S Dite
Carmel Apicella
Helen Tsimiklis
Graham G Giles
Gianluca Severi
Laura Baglietto
Peter A Fasching
Lothar Haeberle
Arif B Ekici
Matthias W Beckmann
Hermann Brenner
Heiko Müller
Volker Arndt
Christa Stegmaier
Anthony Swerdlow
Alan Ashworth
Nick Orr
Michael Jones
Jonine Figueroa
Jolanta Lissowska
Louise Brinton
Mark S Goldberg
France Labrèche
Martine Dumont
Robert Winqvist
Katri Pylkäs
Arja Jukkola-Vuorinen
Mervi Grip
Hiltrud Brauch
Ute Hamann
Thomas Brüning
GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network
Paolo Radice
Paolo Peterlongo
Siranoush Manoukian
Bernardo Bonanni
Peter Devilee
Rob A E M Tollenaar
Caroline Seynaeve
Christi J van Asperen
Anna Jakubowska
Jan Lubinski
Katarzyna Jaworska
Katarzyna Durda
Arto Mannermaa
Vesa Kataja
Veli-Matti Kosma
Jaana M Hartikainen
Natalia V Bogdanova
Natalia N Antonenkova
Thilo Dörk
Vessela N Kristensen
Hoda Anton-Culver
Susan Slager
Amanda E Toland
Stephen Edge
Florentia Fostira
Daehee Kang
Keun-Young Yoo
Dong-Young Noh
Keitaro Matsuo
Hidemi Ito
Hiroji Iwata
Aiko Sueta
Anna H Wu
Chiu-Chen Tseng
David Van Den Berg
Daniel O Stram
Xiao-Ou Shu
Wei Lu
Yu-Tang Gao
Hui Cai
Soo Hwang Teo
Cheng Har Yip
Sze Yee Phuah
Belinda K Cornes
Mikael Hartman
Hui Miao
Wei Yen Lim
Jen-Hwei Sng
Kenneth Muir
Artitaya Lophatananon
Sarah Stewart-Brown
Pornthep Siriwanarangsan
Chen-Yang Shen
Chia-Ni Hsiung
Pei-Ei Wu
Shian-Ling Ding
Suleeporn Sangrajrang
Valerie Gaborieau
Paul Brennan
James McKay
William J Blot
Lisa B Signorello
Qiuyin Cai
Wei Zheng
Sandra Deming-Halverson
Martha Shrubsole
Jirong Long
Jacques Simard
Montse Garcia-Closas
Paul D P Pharoah
Georgia Chenevix-Trench
Alison M Dunning
Javier Benitez
Douglas F Easton

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Laboratory of Translational GenomicsZIACP010201 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI PROKUNINA-OLSSON, LIUDMILA · 2010 to 2025
$91.2M
Southern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0M
The Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI PETER C LUCAS · 2005 to 2026
$49.9M
Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
Premonopausal Hormone Levels and Risk of Breast CancerR01CA067262 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HANKINSON, SUSAN E · 2002 to 2011
$11.9M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3U01CA098233 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HUNTER, DAVID JOHN · 2003 to 2010
$10.8M
Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
Mayo Cancer Genetic Epidemiology Training ProgramR25CA092049 · NCI · MAYO CLINIC ROCHESTER · PI PETERSEN, GLORIA M., VACHON, CELINE M · 2001 to 2018
$5.3M
Shanghai Breast Cancer StudyR01CA064277 · NCI · VANDERBILT UNIVERSITY · PI SHU, XIAO-OU · 1996 to 2012
$4.8M
A genome-wide association study for breast cancer in BRCA1 mutation carriersR01CA128978 · NCI · MAYO CLINIC ROCHESTER · PI COUCH, FERGUS JOSEPH · 2008 to 2012
$4.8M
Breast Cancer Now BREAST CANCER NOW RESEARCH CENTRECancer Research UK 10118Cancer Research UK 10124Cancer Research UK 11022Cancer Research UK 15106Cancer Research UK 16561Cancer Research UK 16565Cancer Research UK C1287/A10118Cancer Research UK C1287/A10710Cancer Research UK C1287/A12014CIHR PSR-SIIRI-701NCI NIH HHS 1 U19 CA 148065-01NCI NIH HHS P30 CA016058NCI NIH HHS P50 CA116201NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA050385NCI NIH HHS R01 CA064277NCI NIH HHS R01 CA065725NCI NIH HHS R01 CA067262NCI NIH HHS R01 CA092447NCI NIH HHS R01 CA100374NCI NIH HHS R01 CA122340NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA148667NCI NIH HHS R01 CA160565NCI NIH HHS R25 CA092049NCI NIH HHS R37 CA070867NCI NIH HHS T32 CA148056NCI NIH HHS U01 CA098233NCI NIH HHS U19 CA148065
6 · The paper itself

Abstract

Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10(-8)). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.

Indexed as

Genetic Predisposition to DiseaseBreast NeoplasmsCase-Control StudiesCooperative BehaviorFemaleGene-Environment InteractionGenetic LociGenome-Wide Association StudyGenotypeHumansMeta-Analysis as TopicPolymorphism, Single NucleotideRisk Factors

Identifiers

PMID23535729
PMCPMC3771688

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.