ArticleRNA biology2013
On the role of four small hairpins in the HIV-1 RNA genome.
Article in RNA biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 15 citations in OpenAlex.
- Role of Mutations in Differential Recognition of Viral RNA Molecules by Peptides.Journal of chemical information and modeling · 2022Article
- Conformational dynamics and energetics of viral RNA recognition by lab-evolved proteins.Physical chemistry chemical physics : PCCP · 2021Article
- Conserved structural RNA domains in regions coding for cleavage site motifs in hemagglutinin genes of influenza viruses.Virus evolution · 2019Article
- New windows into retroviral RNA structures.Retrovirology · 2018Review
- Evaluation of global HIV/SIV envelope gp120 RNA structure and evolution within and among infected hosts.Virus evolution · 2018Article
- Global synonymous mutagenesis identifies cis-acting RNA elements that regulate HIV-1 splicing and replication.PLoS pathogens · 2018Article
- Subtype-specific structural constraints in the evolution of influenza A virus hemagglutinin genes.Scientific reports · 2016Article
- Full-length RNA structure prediction of the HIV-1 genome reveals a conserved core domain.Nucleic acids research · 2015Article
- Structure-Based Alignment and Consensus Secondary Structures for Three HIV-Related RNA Genomes.PLoS computational biology · 2015Article
- Uneven genetic robustness of HIV-1 integrase.Journal of virology · 2015Article
- HIV-1 B-subtype capsid protein: a characterization of amino acid's conservation and its significant association with integrase signatures.Virus genes · 2014Article
- RNA structural constraints in the evolution of the influenza A virus genome NP segment.RNA biology · 2014Article
- Quantifying selection against synonymous mutations in HIV-1 env evolution.Journal of virology · 2013Article
- Changes in the Plasticity of HIV-1 Nef RNA during the Evolution of the North American Epidemic.PloS oneArticle
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An RNA secondary structure model for the complete HIV-1 genome has recently been published based on SHAPE technology. Several well-known RNA motifs such as TAR and RRE were confirmed and numerous new structured motifs were described that may play important roles in virus replication. The 9 kb viral RNA genome is densely packed with many RNA hairpin motifs and the collective fold may play an important role in HIV-1 biology. We initially focused on 16 RNA hairpin motifs scattered along the viral genome. We considered conservation of these structures, despite sequence variation among virus isolates, as a first indication for a significant function. Four relatively small hairpins exhibited considerable structural conservation and were selected for experimental validation in virus replication assays. Mutations were introduced into the HIV-1 RNA genome to destabilize individual RNA structures without affecting the protein-coding properties (silent codon changes). No major virus replication defects were scored, suggesting that these four hairpin structures do not play essential roles in HIV-1 replication.
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