ArticleAnesthesiology2013
Regional lung derecruitment and inflammation during 16 hours of mechanical ventilation in supine healthy sheep.
Article in Anesthesiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Effect of different lung recruitment maneuvers on postoperative respiratory outcomes and lung aeration, assessed by lung ultrasound, in patients undergoing thoracoscopic sympathectomy: a randomized controlled trial.BMC anesthesiology · 2026Trial
- Optimal PEEP Obtained by Titrating Inspiratory Oxygen Fraction Versus Electrical Impedance Tomography in Patients with High Risk of Intraoperative Atelectasis: A Randomized Controlled Trial.Bioengineering (Basel, Switzerland) · 2026Article
- Pathophysiological profile of non-ventilated lung injury in healthy female pigs undergoing mechanical ventilation.Communications medicine · 2024Article
- Worsening of lung perfusion to tissue density distributions during early acute lung injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Intraoperative Protective Mechanical Ventilation: Fact or Fiction?Anesthesiology · 2022Article
- Perioperative Pulmonary Atelectasis: Part II. Clinical Implications.Anesthesiology · 2022Review
- Perioperative Pulmonary Atelectasis: Part I. Biology and Mechanisms.Anesthesiology · 2022Review
- Inflammatory Activity in Atelectatic and Normally Aerated Regions During Early Acute Lung Injury.Academic radiology · 2020Article
- Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep.Anesthesiology · 2020Article
- Mechanical ventilation during thoracic surgery: towards individualized medicine.Annals of translational medicine · 2020Article
- Relation between Respiratory Mechanics, Inflammation, and Survival in Experimental Mechanical Ventilation.American journal of respiratory cell and molecular biology · 2019Article
- The Increasing Call for Protective Ventilation During Anesthesia-Reply.JAMA surgery · 2017Article
- Regional tidal lung strain in mechanically ventilated normal lungs.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Hyperpolarized gas diffusion MRI for the study of atelectasis and acute respiratory distress syndrome.NMR in biomedicine · 2014Review
- Assessing the Progression of Ventilator-Induced Lung Injury in Mice.IEEE transactions on bio-medical engineering · 2013Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLung derecruitment is common during general anesthesia. Mechanical ventilation with physiological tidal volumes could magnify derecruitment, and produce lung dysfunction and inflammation. The authors used positron emission tomography to study the process of derecruitment in normal lungs ventilated for 16 h and the corresponding changes in regional lung perfusion and inflammation.
methodsSix anesthetized supine sheep were ventilated with VT=8 ml/kg and positive end-expiratory pressure=0. Transmission scans were performed at 2-h intervals to assess regional aeration. Emission scans were acquired at baseline and after 16 h for the following tracers: (1) F-fluorodeoxyglucose to evaluate lung inflammation and (2) NN to calculate regional perfusion and shunt fraction.
resultsGas fraction decreased from baseline to 16 h in dorsal (0.31±0.13 to 0.14±0.12, P<0.01), but not in ventral regions (0.61±0.03 to 0.63±0.07, P=nonsignificant), with time constants of 1.5-44.6 h. Although the vertical distribution of relative perfusion did not change from baseline to 16 h, shunt increased in dorsal regions (0.34±0.23 to 0.63±0.35, P<0.01). The average pulmonary net F-fluorodeoxyglucose uptake rate in six regions of interest along the ventral-dorsal direction increased from 3.4±1.4 at baseline to 4.1±1.5 10(-3)/min after 16 h (P<0.01), and the corresponding average regions of interest F-fluorodeoxyglucose phosphorylation rate increased from 2.0±0.2 to 2.5±0.2 10(-2)/min (P<0.01).
conclusionsWhen normal lungs are mechanically ventilated without positive end-expiratory pressure, loss of aeration occurs continuously for several hours and is preferentially localized to dorsal regions. Progressive lung derecruitment was associated with increased regional shunt, implying an insufficient hypoxic pulmonary vasoconstriction. The increased pulmonary net uptake and phosphorylation rates of F-fluorodeoxyglucose suggest an incipient inflammation in these initially normal lungs.
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