ReviewExperimental gerontology2013
Comparing the effects of food restriction and overeating on brain reward systems.
Review in Experimental gerontology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05315635 (Substance Use and Eating Disorders), which is not on this map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Substance Use and Eating Disorders : Food Craving and Addiction Transfer
Who cites it
24 citing papers in PubMed.
- Enhancing Motivation to Reduce Restrictive Eating: A Novel Approach.The International journal of eating disorders · 2025Trial
- Weight Suppression, Brain Reward Response to Food Cues, and Bulimic Behaviours: A Pilot fMRI Study.European eating disorders review : the journal of the Eating Disorders Association · 2026Article
- Early Reward Learning and the Origins of Obesity: Food, Non-Food Reward, and Developing Self-Regulation.Current obesity reports · 2026Review
- Effects of chemotherapy on cognitive and physical effort-based decision-making tasks in rats.Psychopharmacology · 2026Article
- Childhood adversity and disordered eating: the mediator role of food reward drive.Frontiers in psychology · 2026Article
- Weight Cycling Deregulates Eating Behavior in Mice via the Induction of Durable Gut Dysbiosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Early Impact of Bariatric Surgery on Brain Functionality.Journal of metabolic and bariatric surgery · 2025Review
- Food Inhibitory Control and Reward Responsiveness in Healthy Aging.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Striatal signaling tracks naturalistic short-term fluctuations in hunger-satiety.bioRxiv : the preprint server for biology · 2025Article
- Exploring persistence in animal models: The sinking platform test.Journal of neuroscience methods · 2025Review
- Obese-associated gut microbes and derived phenolic metabolite as mediators of excessive motivation for food reward.Microbiome · 2023Article
- Transient food insecurity during the juvenile-adolescent period affects adult weight, cognitive flexibility, and dopamine neurobiology.Current biology : CB · 2022Article
- Associations of parental feeding practices and food reward responsiveness with adolescent stress-eating.Appetite · 2020Article
- Random access to palatable food stimulates similar addiction-like responses as a fixed schedule, but only a fixed schedule elicits anticipatory activation.Scientific reports · 2019Article
- Incorporating food addiction into disordered eating: the disordered eating food addiction nutrition guide (DEFANG).Eating and weight disorders : EWD · 2017Review
- Prevalence of 'Food Addiction' as Measured with the Yale Food Addiction Scale 2.0 in a Representative German Sample and Its Association with Sex, Age and Weight Categories.Obesity facts · 2017Article
- GABA levels in the ventromedial prefrontal cortex during the viewing of appetitive and disgusting food images.Neuroscience · 2016Article
- Pilot clinical observations between food and drug seeking derived from fifty cases attending an eating disorder clinic.Journal of behavioral addictions · 2016Article
- Degeneration of Dopaminergic Neurons Due to Metabolic Alterations and Parkinson's Disease.Frontiers in aging neuroscience · 2016Review
- Mood, food, and obesity.Frontiers in psychology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Both caloric restriction and overeating have been shown to affect neural processes associated with reinforcement. Both preclinical and some clinical studies have provided evidence that food restriction may increase reward sensitivity, and while there are mixed findings regarding the effects of overeating on reward sensitivity, there is strong evidence linking this behavior with changes in reward-related brain regions. Evidence of these changes comes in part from findings that show that such eating patterns are associated with increased drug use. The data discussed here regarding the differential effects of various eating patterns on reward systems may be particularly relevant to the aging population, as this population has been shown to exhibit altered reward sensitivity and decreased caloric consumption. Moreover, members of this population appear to be increasingly affected by the current obesity epidemic. Food, like alcohol or drugs, can stimulate its own consumption and produce similar neurochemical changes in the brain. Age-related loss of appetite, decreased eating, and caloric restriction are hypothesized to be associated with changes in the prevalence of substance misuse, abuse, and dependence seen in this cohort.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.