ArticleThe Journal of toxicological sciences2013
Induction of the fatty acid 2-hydroxylase (FA2H) gene by Δ(9)-tetrahydrocannabinol in human breast cancer cells.
Article in The Journal of toxicological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- A toxicogenomics-based identification of potential mechanisms and signaling pathways involved in PFCs-induced cancer in human.Toxicology research · 2024Review
- ΔForensic toxicology · 2023Article
- FA2H Exhibits Tumor Suppressive Roles on Breast Cancers via Cancer Stemness Control.Frontiers in oncology · 2019Article
- An update on PPAR activation by cannabinoids.British journal of pharmacology · 2016Review
- Active machine learning-driven experimentation to determine compound effects on protein patterns.eLife · 2016Article
- Article
- Article
- Δ(9)-Tetrahydrocannabinol disrupts estrogen-signaling through up-regulation of estrogen receptor β (ERβ).Chemical research in toxicology · 2013Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
To investigate gene(s) being regulated by ∆(9)-tetrahydrocannabinol (∆(9)-THC), we performed DNA microarray analysis of human breast cancer MDA-MB-231 cells, which are poorly differentiated breast cancer cells, treated with ∆(9)-THC for 48 hr at an IC50 concentration of approximately 25 µM. Among the highly up-regulated genes (> 10-fold) observed, fatty acid 2-hydroxylase (FA2H) was significantly induced (17.8-fold). Although the physiological role of FA2H has not yet been fully understood, FA2H has been shown to modulate cell differentiation. The results of Oil Red O staining after ∆(9)-THC exposure showed the distribution of lipid droplets (a sign of the differentiated phenotype) in cells. Taken together, the results obtained here indicate that FA2H is a novel ∆(9)-THC-regulated gene, and that ∆(9)-THC induces differentiation signal(s) in poorly differentiated MDA-MB-231 cells.
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Registered trials
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