Trial reportEuropean journal of heart failure2013
Rationale and design of the SERVE-HF study: treatment of sleep-disordered breathing with predominant central sleep apnoea with adaptive servo-ventilation in patients with chronic heart failure.
Trial report in European journal of heart failure, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Positive airway pressure therapy for the treatment of central sleep apnoea associated with heart failure.The Cochrane database of systematic reviews · 2019Pooled it
- Impact of sleep-disordered breathing and efficacy of positive airway pressure on mortality in patients with chronic heart failure and sleep-disordered breathing: a meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Pooled it
- Effect of adaptive servo-ventilation for central sleep apnoea in systolic heart failure on muscle sympathetic nerve activity: a SERVE-HF randomised ancillary study.The European respiratory journal · 2023Trial
- Effect of adaptive servo ventilation on central sleep apnea and sleep structure in systolic heart failure patients: polysomnography data from the SERVE-HF major sub study.Journal of sleep research · 2022Trial
- Bioprofiles and mechanistic pathways associated with Cheyne-Stokes respiration: insights from the SERVE-HF trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2020Trial
- Biomarkers in patients with heart failure and central sleep apnoea: findings from the SERVE-HF trial.ESC heart failure · 2020Trial
- Validation of a non-contact screening device for the combination of sleep-disordered breathing and periodic limb movements in sleep.Sleep & breathing = Schlaf & Atmung · 2018Trial
- Adaptive servo ventilation for central sleep apnoea in heart failure: SERVE-HF on-treatment analysis.The European respiratory journal · 2017Trial
- Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure.The New England journal of medicine · 2015Trial
- Performance of conventional and enhanced adaptive servoventilation (ASV) in heart failure patients with central sleep apnea who have adapted to conventional ASV.Sleep & breathing = Schlaf & Atmung · 2015Trial
- Short- and long-term effects of nocturnal oxygen therapy on sleep apnea in chronic heart failure.Sleep & breathing = Schlaf & Atmung · 2015Trial
- Prevalence and Impact of Sleep Disordered Breathing in Patients with Severe Aortic Stenosis.PloS one · 2015Trial
- Clinical advantages of reduced expiratory positive airway pressure setting in adaptive servo-ventilation therapy.Heart and vessels · 2025Observational
- Impact of Hypopnoea Classifications on the Assessment of Sleep Disordered Breathing in Heart Failure.Cardiac failure review · 2025Review
- ERS International Congress, Madrid, 2019: highlights from the Sleep and Clinical Physiology Assembly.ERJ open research · 2020Review
- Detecting central sleep apnea in adult patients using WatchPAT-a multicenter validation study.Sleep & breathing = Schlaf & Atmung · 2020Article
- Reduction of sleep-disordered breathing following effective percutaneous mitral valve repair with the MitraClip system.Sleep & breathing = Schlaf & Atmung · 2019Article
- Cardiac adrenergic neuronal activity, sleep apnea, and potential therapeutic role of nocturnal ventilatory assistance in patients with heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Sleep-disordered breathing in patients with cardiovascular diseases cannot be detected by ESS, STOP-BANG, and Berlin questionnaires.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
- Adaptive servo-ventilation to treat central sleep apnea in heart failure with reduced ejection fraction: the Bad Oeynhausen prospective ASV registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsCentral sleep apnoea/Cheyne-Stokes respiration (CSA/CSR) is a risk factor for increased mortality and morbidity in heart failure (HF). Adaptive servo-ventilation (ASV) is a non-invasive ventilation modality for the treatment of CSA/CSR in patients with HF.
methodsSERVE-HF is a multinational, multicentre, randomized, parallel trial designed to assess the effects of addition of ASV (PaceWave, AutoSet CS; ResMed) to optimal medical management compared with medical management alone (control group) in patients with symptomatic chronic HF, LVEF ≤45%, and predominant CSA. The trial is based on an event-driven group sequential design, and the final analysis will be performed when 651 events have been observed or the study is terminated at one of the two interim analyses. The aim is to randomize ∼1200 patients to be followed for a minimum of 2 years. Patients are to stay in the trial up to study termination. The first patient was randomized in February 2008 and the study is expected to end mid 2015. The primary combined endpoint is the time to first event of all-cause death, unplanned hospitalization (or unplanned prolongation of a planned hospitalization) for worsening (chronic) HF, cardiac transplantation, resuscitation of sudden cardiac arrest, or appropriate life-saving shock for ventricular fibrillation or fast ventricular tachycardia in implantable cardioverter defibrillator patients. PERSPECTIVES: The SERVE-HF study is a randomized study that will provide important data on the effect of treatment with ASV on morbidity and mortality, as well as the cost-effectiveness of this therapy, in patients with chronic HF and predominantly CSA/CSR.
trial registrationISRCTN19572887.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.