Evidence map›Paper›PMID 23535140›Full record

ReviewAutonomic neuroscience : basic & clinical2013

Structure activity relationship of synaptic and junctional neurotransmission.

Raj K Goyal, Arun Chaudhury

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Autonomic neuroscience : basic & clinical, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
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  4. Article
  5. Review
  6. Morphology of Schwann Cell Processes Supports Renal Sympathetic Nerve Terminals With Local Distribution of Adrenoceptors.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022
    Article
  7. Article
  8. Review
  9. Review
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  16. Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Raj K GoyalCenter for Swallowing and Motility Disorders, GI Division, VA Boston Healthcare System and Harvard Medical School, Boston, USA. raj_goyal@hms.harvard.edu
Arun Chaudhury

Funding

Nitrergic Neuro-smooth Muscle Transmission in the GutR01DK062867 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GOYAL, RAJ K · 2004 to 2013
$2.7M
PHYSIOLOGY AND PATHOPHYSIOLOGY OF ESOPHAGEAL MOTILITYR01DK031092 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GOYAL, RAJ K · 1994 to 2002
$1.3M
Pathophysiology of Diabetic GastroparesisI01BX002806 · VA · VA BOSTON HEALTH CARE SYSTEM · PI GOYAL, RAJ K · 2016 to 2020
–
BLRD VA I01 BX002806NIDDK NIH HHS DK 062867NIDDK NIH HHS R01 DK031092NIDDK NIH HHS R01 DK062867
6 · The paper itself

Abstract

Chemical neurotransmission may include transmission to local or remote sites. Locally, contact between 'bare' portions of the bulbous nerve terminal termed a varicosity and the effector cell may be in the form of either synapse or non-synaptic contact. Traditionally, all local transmissions between nerves and effector cells are considered synaptic in nature. This is particularly true for communication between neurons. However, communication between nerves and other effectors such as smooth muscles has been described as nonsynaptic or junctional in nature. Nonsynaptic neurotransmission is now also increasingly recognized in the CNS. This review focuses on the relationship between structure and function that orchestrate synaptic and junctional neurotransmissions. A synapse is a specialized focal contact between the presynaptic active zone capable of ultrafast release of soluble transmitters and the postsynaptic density that cluster ionotropic receptors. The presynaptic and the postsynaptic areas are separated by the 'closed' synaptic cavity. The physiological hallmark of the synapse is ultrafast postsynaptic potentials lasting milliseconds. In contrast, junctions are juxtapositions of nerve terminals and the effector cells without clear synaptic specializations and the junctional space is 'open' to the extracellular space. Based on the nature of the transmitters, postjunctional receptors and their separation from the release sites, the junctions can be divided into 'close' and 'wide' junctions. Functionally, the 'close' and the 'wide' junctions can be distinguished by postjunctional potentials lasting ~1s and tens of seconds, respectively. Both synaptic and junctional communications are common between neurons; however, junctional transmission is the rule at many neuro-non-neural effectors.

Indexed as

AnimalsGap JunctionsHumansPresynaptic TerminalsReceptors, NeurotransmitterStructure-Activity RelationshipSynapsesSynaptic PotentialsSynaptic TransmissionReceptors, Neurotransmitter

Identifiers

PMID23535140
PMCPMC3677731

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.