ArticleThe Journal of allergy and clinical immunology2013
Maternal asthma and microRNA regulation of soluble HLA-G in the airway.
Article in The Journal of allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- Trial
- Immune Training of the Interleukin 6 Gene in Airway Epithelial Cells is Central to Asthma Exacerbations.Allergy · 2026Article
- MicroRNAs in Asthma: A Replication-Based Review of Human Evidence.Journal of inflammation research · 2026Review
- The + 3010/C single nucleotide polymorphism (rs1710) at the HLA-G 3' untranslated region is associated with a short transcript exhibiting a deletion of 92 nucleotides.Immunogenetics · 2023Article
- Non-Coding RNAs in Pulmonary Diseases: Comparison of Different Airway-Derived Biosamples.International journal of molecular sciences · 2023Review
- DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- HLA-G in Allergy: Does It Play an Immunoregulatory Role?Frontiers in immunology · 2021Review
- Epigenetics in Asthma.Current allergy and asthma reports · 2019Review
- Article
- Interaction network of coexpressed mRNA, miRNA, and lncRNA activated by TGF‑β1 regulates EMT in human pulmonary epithelial cell.Molecular medicine reports · 2017Article
- Elevated levels of soluble humanleukocyte antigen-G in the airways are a marker for a low-inflammatory endotype of asthma.The Journal of allergy and clinical immunology · 2017Observational
- Is MicroRNA-127 a Novel Biomarker for Acute Pancreatitis with Lung Injury?Disease markers · 2017Article
- Bronchial Epithelial Cells from Asthmatic Patients Display Less Functional HLA-G Isoform Expression.Frontiers in immunology · 2017Article
- DNA methylation in lung cells is associated with asthma endotypes and genetic risk.JCI insight · 2016Article
- The genetic and epigenetic landscapes of the epithelium in asthma.Respiratory research · 2016Review
- Corticosteroid therapy and airflow obstruction influence the bronchial microbiome, which is distinct from that of bronchoalveolar lavage in asthmatic airways.The Journal of allergy and clinical immunology · 2016Article
- MicroRNA regulation of allergic inflammation and asthma.Current opinion in immunology · 2015Review
- Identification of microRNAs associated with allergic airway disease using a genetically diverse mouse population.BMC genomics · 2015Article
- A polymorphism in HLA-G modifies statin benefit in asthma.The pharmacogenomics journal · 2015Article
- Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens.The World Allergy Organization journal · 2015Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWe previously reported an interaction between maternal asthma and the child's HLA-G genotype on the child's subsequent risk for asthma. The implicated single nucleotide polymorphism at +3142 disrupted a target site for the microRNA (miR)-152 family. We hypothesized that the interaction effect might be mediated by these miRs.
objectiveThe objective of this study was to test this hypothesis in adults with asthma who are a subset of the same subjects who participated in our earlier family-based studies.
methodsWe measured soluble HLA-G (sHLA-G) concentrations in bronchoalveolar lavage fluid (n = 36) and plasma (n = 57) from adult asthmatic subjects with and without a mother with asthma, and HLA-G and miR-152 family (miR-148a, miR-148b, and miR-152) transcript levels in airway epithelial cells from the same subjects.
resultsmiR-148b levels were significantly increased in airway epithelial cells from asthmatic subjects with an asthmatic mother compared with those seen in asthmatic subjects without an asthmatic mother, and +3142 genotypes were associated with sHLA-G concentrations in bronchoalveolar lavage fluid among asthmatic subjects with an asthmatic mother but not among those with a nonasthmatic mother. Neither effect was observed in the plasma (sHLA-G) or white blood cells (miRNA).
conclusionThese combined results are consistent with +3142 allele-specific targeting of HLA-G by the miR-152 family and support our hypothesis that miRNA regulation of sHLA-G in the airway is influenced by both the asthma status of the subject's mother and the subject's genotype. Moreover, we demonstrate that the effects of maternal asthma on the gene regulatory landscape in the airways of the mother's children persist into adulthood.
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