Evidence map›Paper›PMID 23534947›Full record

ArticleThe American journal of managed care2013

Measuring concurrent oral hypoglycemic and antidepressant adherence and clinical outcomes.

Hillary R Bogner, Heather F de Vries, Alison J O'Donnell, Knashawn H Morales

Abstract read
PubMed Full text at PMC
In one paragraph

Article in The American journal of managed care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hillary R BognerCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, The University of Pennsylvania, 9 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104, USA. hillary.bogner@uphs.upenn.edu
Heather F de Vries
Alison J O'Donnell
Knashawn H Morales
University of Pennsylvania · US

Funding

EVOLUTION OF PSYCHOPATHOLOGY IN THE POPULATIONR01MH047447 · NIMH · JOHNS HOPKINS UNIVERSITY · PI EATON, WILLIAM W · 1992 to 2006
$5.3M
Course and risk factors for depression in late lifeR01MH082799 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BOGNER, HILLARY R · 2009 to 2010
$798k
Measurement Error in Latent Class Models of AdherenceK01MH073903 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MORALES, KNASHAWN HODGE · 2007 to 2011
$689k
NIMH NIH HHS K01 MH073903NIMH NIH HHS MH047447NIMH NIH HHS MH073903NIMH NIH HHS MH082799NIMH NIH HHS R01 MH047447NIMH NIH HHS R01 MH082799
6 · The paper itself

Abstract

objectivesMany patients experience difficulty in adhering to medication for both physical and mental health. Our objective was to compare selfreported adherence and electronic monitoring of adherence to oral hypoglycemic agents and antidepressants and to examine the relationship of adherence with clinical outcomes. STUDY

designPrimary care-based longitudinal study.

methodsAdherence was assessed in 180 patients prescribed pharmacotherapy for type 2 diabetes mellitus (T2DM) and depression enrolled in a randomized controlled trial of an integrated intervention for depression and T2DM. Adherence data were collected using self report and electronic monitoring. Glycated hemoglobin (A1C) assays were used to measure glycemic control, and the 9-item patient health questionnaire assessed depression.

resultsAt 12 weeks, self-reported adherence and electronic monitoring of adherence showed fair agreement (kappa = 0.213, P = .004 for oral hypoglycemic agents and kappa = 0.380, P < .001 for antidepressants). Patients who achieved >80% adherence to oral hypoglycemic agents measured with electronic monitoring were more likely to achieve A1C < 7% compared with patients who did not achieve > 80% adherence at 12 weeks (adjusted odds ratio = 3.52, 95% confidence interval 1.07-11.57). Self-reported adherence to oral hypoglycemic agents was not associated with diabetes outcomes. Measures of adherence for antidepressants were not associated with depression outcomes in models adjusted for potentially influential covariates.

conclusionsCompared with electronic monitoring of adherence, self-reported adherence tended to overestimate medication adherence. Electronic monitoring of adherence to oral hypoglycemic agents predicted glycemic control, but self-reported adherence did not predict clinical outcomes.

Indexed as

Drug MonitoringAdministration, OralAntidepressive AgentsDepressionDiabetes Mellitus, Type 2Glycated HemoglobinHumansHypoglycemic AgentsLongitudinal StudiesMedication AdherencePhiladelphiaTreatment OutcomeAntidepressive AgentsGlycated HemoglobinHypoglycemic Agents

Identifiers

PMID23534947
PMCPMC4094025
OpenAlexW42742673

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.