ArticleAnalytical chemistry2013
Isomer-specific LC/MS and LC/MS/MS profiling of the mouse serum N-glycome revealing a number of novel sialylated N-glycans.
Article in Analytical chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Dual role of lactate in ferroptosis: Mechanisms, pathophysiology and therapeutic opportunities (Review).International journal of molecular medicine · 2026Review
- Lactylation in Tumor Immune Escape and Immunotherapy: Multifaceted Functions and Therapeutic Strategies.Research (Washington, D.C.) · 2025Review
- Article
- Temporal quantitative profiling of sialyllactoses and sialic acids after oral administration of sialyllactose to mini-pigs with osteoarthritis.RSC advances · 2023Article
- Highly sensitive characterization of non-human glycan structures of monoclonal antibody drugs utilizing tandem mass spectrometry.Scientific reports · 2022Article
- Article
- In-depth characterization of non-human sialic acid (Neu5Gc) in human serum using label-free ZIC-HILIC/MRM-MS.Analytical and bioanalytical chemistry · 2021Article
- Spatial and temporal diversity of glycome expression in mammalian brain.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Discovery of N-glycan Biomarkers for the Canine Osteoarthritis.Life (Basel, Switzerland) · 2020Article
- An improved method for the purification of milk oligosaccharides by graphitised carbon-solid phase extraction.International dairy journal · 2018Article
- Building a PGC-LC-MS N-glycan retention library and elution mapping resource.Glycoconjugate journal · 2018Article
- Stage Dependence, Cell-Origin Independence, and Prognostic Capacity of Serum Glycan Fucosylation, β1-4 Branching, β1-6 Branching, and α2-6 Sialylation in Cancer.Journal of proteome research · 2018Article
- Studying Lactoferrin N-Glycosylation.International journal of molecular sciences · 2017Review
- Comprehensive N-Glycan Profiling of Cetuximab Biosimilar Candidate by NP-HPLC and MALDI-MS.PloS one · 2017Article
- Acute phase inflammation is characterized by rapid changes in plasma/peritoneal fluid N-glycosylation in mice.Glycoconjugate journal · 2016Article
- Microfluidic Chip-LC/MS-based Glycomic Analysis Revealed Distinct N-glycan Profile of Rat Serum.Scientific reports · 2015Article
- Characterization of goat milk lactoferrin N-glycans and comparison with the N-glycomes of human and bovine milk.Electrophoresis · 2014Article
- Differentiation of cancer cell origin and molecular subtype by plasma membrane N-glycan profiling.Journal of proteome research · 2014Article
- Engineering hydrophobic protein-carbohydrate interactions to fine-tune monoclonal antibodies.Journal of the American Chemical Society · 2013Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Mice are the premier mammalian models for studies of human physiology and disease, bearing extensive biological similarity to humans with far fewer ethical, economic, or logistic complications. To facilitate glycomic studies based on the mouse model, we comprehensively profiled the mouse serum N-glycome using isomer-specific nano-LC/MS and -LC/MS/MS. N-Glycans were identified by accurate mass MS and structurally elucidated by MS/MS. Porous graphitized carbon nano-LC was able to separate out nearly 300 N-linked glycan compounds (including isomers) from just over 100 distinct N-linked glycan compositions. Additional MS/MS structural analysis was performed on a number of novel N-glycans, revealing the structural characteristics of modifications such as dehydration, O-acetylation, and lactylation. Experimental findings were combined with known glycobiology to generate a theoretical library of all biologically possible mouse serum N-glycan compositions. The library may be used for automated identification of complex mixtures of mouse N-glycans, with possible applications to a wide range of mouse-related research endeavors, including pharmaceutical drug development and biomarker discovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.