ArticleJournal of neurotrauma2013
Long-term in vivo imaging of viscoelastic properties of the mouse brain after controlled cortical impact.
Article in Journal of neurotrauma, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- The effects of blast-induced traumatic brain injury on brain cellular mechanics and differentiation.PloS one · 2026Article
- Mechanobiology of the blood-brain barrier during development, disease and ageing.Nature communications · 2025Review
- Development of a Three-Dimensional Pathology-Simulating Model of Neurotrauma Using a Polymer-Encapsulated Neural Cell Network.Gels (Basel, Switzerland) · 2025Article
- Viscoelastic High-Molecular-Weight Hyaluronic Acid Hydrogels Support Rapid Glioblastoma Cell Invasion with Leader-Follower Dynamics.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- The Networking Brain: How Extracellular Matrix, Cellular Networks, and Vasculature Shape the In Vivo Mechanical Properties of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Viscoelastic high-molecular-weight hyaluronic acid hydrogels support rapid glioblastoma cell invasion with leader-follower dynamics.bioRxiv : the preprint server for biology · 2024Article
- Mechanical behavior and microstructure of porcine brain tissues under pulsed electric fields.Biomechanics and modeling in mechanobiology · 2024Article
- Mechanical stiffness and anisotropy measured by MRE during brain development in the minipig.NeuroImage · 2023Article
- Advanced Neuroimaging Role in Traumatic Brain Injury: A Narrative Review.Frontiers in neuroscience · 2022Review
- Mechanosensation in traumatic brain injury.Neurobiology of disease · 2021Review
- Standard-space atlas of the viscoelastic properties of the human brain.Human brain mapping · 2020Article
- Stiffness and Beyond: What MR Elastography Can Tell Us About Brain Structure and Function Under Physiologic and Pathologic Conditions.Topics in magnetic resonance imaging : TMRI · 2018Review
- Pre-clinical MR elastography: Principles, techniques, and applications.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018Review
- Magnetic Resonance Elastography of Rodent Brain.Frontiers in neurology · 2018Review
- Lateral Ventricle Attenuates Underlying Traumatic Axonal Injury after Closed Head Injury in the Mouse.Journal of neurotrauma · 2017Article
- Specificity protein 1-zinc finger protein 179 pathway is involved in the attenuation of oxidative stress following brain injury.Redox biology · 2017Article
- Hypocretinergic and cholinergic contributions to sleep-wake disturbances in a mouse model of traumatic brain injury.Neurobiology of sleep and circadian rhythms · 2017Article
- Abnormal Injury Response in Spontaneous Mild Ventriculomegaly Wistar Rat Brains: A Pathological Correlation Study of Diffusion Tensor and Magnetization Transfer Imaging in Mild Traumatic Brain Injury.Journal of neurotrauma · 2017Article
- Granulocyte-macrophage colony stimulating factor exerts protective and immunomodulatory effects in cortical trauma.Journal of neuroimmunology · 2015Article
- Traumatic brain injury using mouse models.Translational stroke research · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Traumatic brain injury (TBI) presents a variety of causes and symptoms, thus making the development of reliable diagnostic methods and therapeutic treatments challenging. Magnetic resonance elastography (MRE) is a technique that allows for a noninvasive assessment of the mechanical properties of soft biological tissue, such as tissue stiffness, storage modulus, and loss modulus. Importantly, by quantifying the changes in the stiffness of tissue that is often associated with disease, MRE is able to detect tissue pathologies at early stages. Recent improvements in instrumentation have allowed for the investigation of small samples with microscopic resolution (μMRE). We hypothesize that μMRE can sensitively detect variations in micromechanical properties in the brain caused by the compressive and shearing forces sustained during TBI. To test this hypothesis, we randomized 13 C57BL mice to receive a controlled cortical impact at a 0.5 mm or 0.75 mm depth, with both sham and naïve mice as controls. Our objective was to propagate mechanical shear waves throughout the brain for in vivo TBI μMRE imaging. The mechanical properties of the injured brain tissue were determined at days 0, 1, 7, and 28 post-injury. For both groups, we observed a significant drop in the stiffness of the impacted region immediately following the injury; the 0.75 mm animals experienced increased tissue softness that lasted longer than that for the 0.5 mm group. Although the shear stiffness, storage modulus, and loss modulus parameters all followed the same trend, the tissue stiffness yielded the most statistically significant results. Overall, this article introduces a transformative technique for mechanically mapping the brain and detecting brain diseases and injury.
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