Evidence map›Paper›PMID 23534358›Full record

ReviewFuture microbiology2013

Bacterial oncogenesis in the colon.

Christine Dejea, Elizabeth Wick, Cynthia L Sears

Open access · greenAbstract readReview
In one paragraph

Review in Future microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 88 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Heliyon · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Antibody response to enterotoxigenicAsian biomedicine : research, reviews and news · 2023
    Article
  11. Article
  12. Article
  13. Review
  14. Anti-cancer activity of human gastrointestinal bacteria.Medical oncology (Northwood, London, England) · 2022
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Christine DejeaDepartment of Molecular Microbiology & Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA.
Elizabeth Wick
Cynthia L Sears
Johns Hopkins Medicine · USJohns Hopkins University · USSidney Kimmel Comprehensive Cancer Center · US

Funding

Training: Molecular & Cellular Bases of Infectious DiseasesT32AI007417 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall · 1994 to 2026
$11.9M
PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXINR01DK045496 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEARS, CYNTHIA · 1993 to 2010
$3.6M
The Role of Polyamine Oxidase in Antitumor Drug ResponseR01CA098454 · NCI · JOHNS HOPKINS UNIVERSITY · PI CASERO, ROBERT A. · 2003 to 2013
$2.9M
Enterotoxigenic Bacteroides fragilis: A bacterial promoter of colon oncogenesisR01CA151393 · NCI · JOHNS HOPKINS UNIVERSITY · PI PARDOLL, DREW M., SEARS, CYNTHIA · 2010 to 2014
$2.7M
Mechanisms of Interleukin-17 Inflammation Induced by Bacteroides fragilisR01DK080817 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEARS, CYNTHIA · 2008 to 2012
$1.7M
Mechanisms of TH17 Inflammation-Induced Colon CarcihogenesisR01CA151325 · NCI · JOHNS HOPKINS UNIVERSITY · PI PARDOLL, DREW M., SEARS, CYNTHIA · 2010 to 2014
$1.6M
Role of Stat3 in Colonic InflammationK08DK087856 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WICK, ELIZABETH C · 2010 to 2014
$788k
NCI NIH HHS R01 CA098454NCI NIH HHS R01CA098454NCI NIH HHS R01 CA151325NCI NIH HHS R01CA151325NCI NIH HHS R01 CA151393NCI NIH HHS R01CA151393NIAID NIH HHS T32 AI007417NIAID NIH HHS T32AI007417NIDDK NIH HHS K08 DK087856NIDDK NIH HHS K08DK087856NIDDK NIH HHS R01 DK045496NIDDK NIH HHS R01 DK080817NIDDK NIH HHS R01DK080817
6 · The paper itself

Abstract

The human colon plays host to a diverse and metabolically complex community of microorganisms. While the colonic microbiome has been suggested to contribute to the development of colorectal cancer (CRC), a definitive link has not been made. The role in which the colon microflora could contribute to the initiation and/or progression of CRC is explored in this review. Potential mechanisms of bacterial oncogenesis are presented, along with lines of evidence derived from animal models of microbially induced CRC. Particular focus is given to the oncogenic capabilities of enterotoxigenic Bacteroides fragilis. Recent progress in defining the microbiome of CRC in the human population is evaluated, and the future challenges of linking specific etiologic agents to CRC are emphasized.

Indexed as

Bacterial Physiological PhenomenaAnimalsBacteriaBacterial InfectionsColonColorectal NeoplasmsHumans

Identifiers

PMID23534358
PMCPMC4052711
OpenAlexW2022169717

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.