ArticleThe Annals of otology, rhinology, and laryngology2013
Visualizing collagen network within human and rhesus monkey vocal folds using polarized light microscopy.
Article in The Annals of otology, rhinology, and laryngology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- A proposal for epithelial dominance in extremely high fundamental frequency vocalizations.The Journal of the Acoustical Society of America · 2025Article
- Magnetic Alignment of Collagen: Principles, Methods, Applications, and Fiber Alignment Analyses.Tissue engineering. Part B, Reviews · 2024Review
- Insights Into the Role of Collagen in Vocal Fold Health and Disease.Journal of voice : official journal of the Voice Foundation · 2017Review
- High- and ultrahigh-field magnetic resonance imaging of naïve, injured and scarred vocal fold mucosae in rats.Disease models & mechanisms · 2016Article
- Combining multiobjective optimization and cluster analysis to study vocal fold functional morphology.IEEE transactions on bio-medical engineering · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesCollagen fiber content and orientation affect the viscoelastic properties of the vocal folds, determining oscillation characteristics during speech and other vocalization. The investigation and reconstruction of the collagen network in vocal folds remains a challenge, because the collagen network requires at least micron-scale resolution. In this study, we used polarized light microscopy to investigate the distribution and alignment of collagen fibers within the vocal folds.
methodsData were collected in sections of human and rhesus monkey (Macaca mulatta) vocal folds cut at 3 different angles and stained with picrosirius red.
resultsStatistically significant differences were found between different section angles, implying that more than one section angle is required to capture the network's complexity. In the human vocal folds, the collagen fiber distribution continuously varied across the lamina propria (medial to lateral). Distinct differences in birefringence distribution were observed between the species. For the human vocal folds, high birefringence was observed near the thyroarytenoid muscle and near the epithelium. However, in the rhesus monkey vocal folds, high birefringence was observed near the epithelium, and lower birefringence was seen near the thyroarytenoid muscle.
conclusionsThe differences between the collagen networks in human and rhesus monkey vocal folds provide a morphological basis for differences in viscoelastic properties between species.
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Registered trials
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