ArticleJournal of amino acids2013
Urotensin-II Ligands: An Overview from Peptide to Nonpeptide Structures.
Article in Journal of amino acids, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 17 citations in OpenAlex.
- Understanding Peptide Binding in Class A G Protein-Coupled Receptors.Molecular pharmacology · 2019Review
- Urotensin-II-Targeted Liposomes as a New Drug Delivery System towards Prostate and Colon Cancer Cells.Journal of oncology · 2019Article
- Urotensin II receptor determines prognosis of bladder cancer regulating cell motility/invasion.Journal of experimental & clinical cancer research : CR · 2014Article
- A new therapeutic approach to erectile dysfunction: urotensin-II receptor high affinity agonist ligands.Asian journal of andrologyArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urotensin-II was originally isolated from the goby urophysis in the 1960s as a vasoactive peptide with a prominent role in cardiovascular homeostasis. The identification of human isoform of urotensin-II and its specific UT receptor by Ames et al. in 1999 led to investigating the putative role of the interaction U-II/UT receptor in multiple pathophysiological effects in humans. Since urotensin-II is widely expressed in several peripheral tissues including cardiovascular system, the design and development of novel urotensin-II analogues can improve knowledge about structure-activity relationships (SAR). In particular, since the modulation of the U-II system offers a great potential for therapeutic strategies related to the treatment of several diseases, like cardiovascular diseases, the research of selective and potent ligands at UT receptor is more fascinating. In this paper, we review the developments of peptide and nonpeptide U-II structures so far developed in order to contribute also to a more rational and detectable design and synthesis of new molecules with high affinity at the UT receptor.
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Registered trials
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