Trial reportPloS one2013
Cortical depth dependent functional responses in humans at 7T: improved specificity with 3D GRASE.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 182 citations in OpenAlex.
- Trial
- Whole-brain three-dimensional T2-weighted BOLD functional magnetic resonance imaging at 7 Tesla.Magnetic resonance in medicine · 2014Trial
- A synthetic 3D human cerebrovascular model informed by histology for simulating the cortical depth-dependent BOLD fMRI signal.PLoS computational biology · 2026Article
- UltraFast Layer-Resolved Encoding (uFLARE) functional MRI deciphers bidirectional signaling from spontaneous activity.Nature communications · 2026Article
- Next Generation 7 Tesla Arterial Spin Labeling With Rotated Spiral Acquisition Enables Mesoscale Resolution in 3D Brain Perfusion and Functional MRI.Magnetic resonance in medicine · 2026Article
- Testing circuit-level theories of consciousness in humans.Trends in cognitive sciences · 2026Review
- Unraveling the mesoscale resting-state functional connectivity of ocular dominance columns in humans using high-resolution functional MRI.Communications biology · 2025Article
- Unraveling the mesoscale resting-state functional connectivity of ocular dominance columns in humans using high-resolution functional MRI.bioRxiv : the preprint server for biology · 2025Article
- Cortical-layer EEG-fMRI at 7T: experimental setup and analysis pipeline to elucidate generating mechanisms of alpha oscillations.bioRxiv : the preprint server for biology · 2025Article
- Higher spatial resolution and sensitivity in whole brain functional MRI at 7T using 3D EPI accelerated with variable density CAIPI sampling and temporal random walk.Magnetic resonance in medicine · 2025Article
- Layer-specific BOLD effects in gradient and spin-echo acquisitions in somatosensory cortex.Magnetic resonance in medicine · 2025Article
- Differential Impacts of Strabismic and Anisometropic Amblyopia on the Mesoscale Functional Organization of the Human Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Impact of vascular architecture, oxygen saturation, and hematocrit on human cortical depth-dependent GE- and SE-BOLD fMRI signals: A simulation approach using realistic 3D vascular networks.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Mapping curvature domains in human V4 using CBV-sensitive layer-fMRI at 3T.Frontiers in neuroscience · 2025Article
- Optimization and validation of multi-echo, multi-contrast SAGE acquisition in fMRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A fully synthetic three-dimensional human cerebrovascular model based on histological characteristics to investigate the hemodynamic fingerprint of the layer BOLD fMRI signal formation.bioRxiv : the preprint server for biology · 2024Article
- Article
- Using high-resolution functional MRI to differentiate impacts of strabismic and anisometropic amblyopia on evoked ocular dominance activity in humans.bioRxiv : the preprint server for biology · 2024Article
- Cortical depth profiles in primary visual cortex for illusory and imaginary experiences.Nature communications · 2024Article
- Imaging the columnar functional organization of human area MT+ to axis-of-motion stimuli using VASO at 7 Tesla.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Ultra high fields (7T and above) allow functional imaging with high contrast-to-noise ratios and improved spatial resolution. This, along with improved hardware and imaging techniques, allow investigating columnar and laminar functional responses. Using gradient-echo (GE) (T2* weighted) based sequences, layer specific responses have been recorded from human (and animal) primary visual areas. However, their increased sensitivity to large surface veins potentially clouds detecting and interpreting layer specific responses. Conversely, spin-echo (SE) (T2 weighted) sequences are less sensitive to large veins and have been used to map cortical columns in humans. T2 weighted 3D GRASE with inner volume selection provides high isotropic resolution over extended volumes, overcoming some of the many technical limitations of conventional 2D SE-EPI, whereby making layer specific investigations feasible. Further, the demonstration of columnar level specificity with 3D GRASE, despite contributions from both stimulated echoes and conventional T2 contrast, has made it an attractive alternative over 2D SE-EPI. Here, we assess the spatial specificity of cortical depth dependent 3D GRASE functional responses in human V1 and hMT by comparing it to GE responses. In doing so we demonstrate that 3D GRASE is less sensitive to contributions from large veins in superficial layers, while showing increased specificity (functional tuning) throughout the cortex compared to GE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.