ArticlePloS one2013
Integrated proteomics and metabolomics of Arabidopsis acclimation to gene-dosage dependent perturbation of isopropylmalate dehydrogenases.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 29 citations in OpenAlex.
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- Three-in-One Simultaneous Extraction of Proteins, Metabolites and Lipids for Multi-Omics.Frontiers in genetics · 2021Article
- Protective role of nitric oxide on nitrogen-thiol metabolism and amino acids profiling during arsenic exposure in Oryza sativa L.Ecotoxicology (London, England) · 2020Article
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- Biotechnological approaches in glucosinolate production.Journal of integrative plant biology · 2018Review
- Proteomics and Phosphoproteomics of Heat Stress-Responsive Mechanisms in Spinach.Frontiers in plant science · 2018Article
- Whole genome duplication enhances the photosynthetic capacity of Chrysanthemum nankingense.Molecular genetics and genomics : MGG · 2017Article
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- Proteomic analysis of amino acid metabolism differences between wild and cultivated Panax ginseng.Journal of ginseng research · 2016Article
- Optimization of Engineered Production of the Glucoraphanin Precursor Dihomomethionine in Nicotiana benthamiana.Frontiers in bioengineering and biotechnology · 2016Article
- Combined Metabolomics and Proteomics Analysis of Major Depression in an Animal Model: Perturbed Energy Metabolism in the Chronic Mild Stressed Rat Cerebellum.Omics : a journal of integrative biology · 2015Article
- Thiol-based redox proteins in abscisic acid and methyl jasmonate signaling in Brassica napus guard cells.The Plant journal : for cell and molecular biology · 2014Article
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Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maintaining metabolic homeostasis is critical for plant growth and development. Here we report proteome and metabolome changes when the metabolic homeostasis is perturbed due to gene-dosage dependent mutation of Arabidopsis isopropylmalate dehydrogenases (IPMDHs). By integrating complementary quantitative proteomics and metabolomics approaches, we discovered that gradual ablation of the oxidative decarboxylation step in leucine biosynthesis caused imbalance of amino acid homeostasis, redox changes and oxidative stress, increased protein synthesis, as well as a decline in photosynthesis, which led to rearrangement of central metabolism and growth retardation. Disruption of IPMDHs involved in aliphatic glucosinolate biosynthesis led to synchronized increase of both upstream and downstream biosynthetic enzymes, and concomitant repression of the degradation pathway, indicating metabolic regulatory mechanisms in controlling glucosinolate biosynthesis.
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