ArticlePloS one2013
Multi-allelic major effect genes interact with minor effect QTLs to control adaptive color pattern variation in Heliconius erato.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Recombinant inbred line panels inform the genetic architecture and interactions of adaptive traits in Drosophila melanogaster.G3 (Bethesda, Md.) · 2025Article
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- Many functionally connected loci foster adaptive diversification along a neotropical hybrid zone.Science advances · 2020Article
- The genomics of coloration provides insights into adaptive evolution.Nature reviews. Genetics · 2020Review
- Perfect mimicry betweenProceedings. Biological sciences · 2020Article
- The genetic architecture of adaptation: convergence and pleiotropy in Heliconius wing pattern evolution.Heredity · 2019Article
- Phenotypic variation inInterface focus · 2019Article
- Waiting in the wings: what can we learn about gene co-option from the diversification of butterfly wing patterns?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Complex modular architecture around a simple toolkit of wing pattern genes.Nature ecology & evolution · 2017Article
- Evolutionary Novelty in a Butterfly Wing Pattern through Enhancer Shuffling.PLoS biology · 2016Article
- Divergence with gene flow across a speciation continuum of Heliconius butterflies.BMC evolutionary biology · 2015Article
- Conservatism and novelty in the genetic architecture of adaptation in Heliconius butterflies.Heredity · 2015Article
- The functional basis of wing patterning in Heliconius butterflies: the molecules behind mimicry.Genetics · 2015Review
- Towards the identification of the loci of adaptive evolution.Methods in ecology and evolution · 2015Review
- A predictive model for canine dilated cardiomyopathy-a meta-analysis of Doberman Pinscher data.PeerJ · 2015Article
- Population genomics of parallel hybrid zones in the mimetic butterflies, H. melpomene and H. erato.Genome research · 2014Article
- Multiple recent co-options of Optix associated with novel traits in adaptive butterfly wing radiations.EvoDevo · 2014Article
- Migration-selection balance at multiple Loci and selection on dominance and recombination.PloS one · 2014Article
- Detecting adaptive trait loci in nonmodel systems: divergence or admixture mapping?Molecular ecology · 2013Article
- Article
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Authors and funding
9 authors at 8 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies indicate that relatively few genomic regions are repeatedly involved in the evolution of Heliconius butterfly wing patterns. Although this work demonstrates a number of cases where homologous loci underlie both convergent and divergent wing pattern change among different Heliconius species, it is still unclear exactly how many loci underlie pattern variation across the genus. To address this question for Heliconius erato, we created fifteen independent crosses utilizing the four most distinct color pattern races and analyzed color pattern segregation across a total of 1271 F2 and backcross offspring. Additionally, we used the most variable brood, an F2 cross between H. himera and the east Ecuadorian H. erato notabilis, to perform a quantitative genetic analysis of color pattern variation and produce a detailed map of the loci likely involved in the H. erato color pattern radiation. Using AFLP and gene based markers, we show that fewer major genes than previously envisioned control the color pattern variation in H. erato. We describe for the first time the genetic architecture of H. erato wing color pattern by assessing quantitative variation in addition to traditional linkage mapping. In particular, our data suggest three genomic intervals modulate the bulk of the observed variation in color. Furthermore, we also identify several modifier loci of moderate effect size that contribute to the quantitative wing pattern variation. Our results are consistent with the two-step model for the evolution of mimetic wing patterns in Heliconius and support a growing body of empirical data demonstrating the importance of major effect loci in adaptive change.
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