ArticleEvidence-based complementary and alternative medicine : eCAM2013
Inhibitory effects of traditional herbal formula pyungwi-san on inflammatory response in vitro and in vivo.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- In Silico Analysis of Pyeongwi-San Involved in Inflammatory Bowel Disease Treatment Using Network Pharmacology, Molecular Docking, and Molecular Dynamics.Biomolecules · 2023Article
- Complementary and alternative medicine for functional dyspepsia: An Asian perspective.Medicine · 2022Article
- Hydroethanolic Extract of DefattedMedicines (Basel, Switzerland) · 2021Article
- Anti-inflammatory, expectorant, and antitussive properties ofPharmaceutical biology · 2021Article
- Traditional Chinese Medicine Enhances Survival in Patients with Gastric Cancer after Surgery and Adjuvant Chemotherapy in Taiwan: A Nationwide Matched Cohort Study.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Preventive Effects ofInternational journal of molecular sciences · 2019Article
- Anti-inflammatory and utero-relaxant effect of α-bisabolol on the pregnant human uterus.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2018Article
- Functional components in Scutellaria barbata D. Don with anti-inflammatory activity on RAW 264.7 cells.Journal of food and drug analysis · 2018Article
- Cheongsangbangpung-tang ameliorated the acute inflammatory response via the inhibition of NF-κB activation and MAPK phosphorylation.BMC complementary and alternative medicine · 2017Article
- Evaluation of anti-inflammatory activity of compounds isolated from the rhizome of Ophiopogon japonicas.BMC complementary and alternative medicine · 2017Article
- Chemical composition and anti-inflammatory activities of essential oil from Trachydium roylei.Journal of food and drug analysis · 2016Article
- Chemomics-Integrated Proteomics Analysis of Jie-Geng-Tang to Ameliorate Lipopolysaccharide-Induced Acute Lung Injury in Mice.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- The antioxidant effects of isorhamnetin contribute to inhibit COX-2 expression in response to inflammation: a potential role of HO-1.Inflammation · 2014Article
- U-Bang-Haequi Tang: A Herbal Prescription that Prevents Acute Inflammation through Inhibition of NF-κB-Mediated Inducible Nitric Oxide Synthase.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Houttuynia cordata Thunb inhibits the production of pro-inflammatory cytokines through inhibition of the NFκB signaling pathway in HMC-1 human mast cells.Molecular medicine reports · 2013Article
- Chemical composition and anti-inflammatory effects of essential oil from Hallabong flower.EXCLI journal · 2013Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyungwi-san (PWS) is a traditional basic herbal formula. We investigated the effects of PWS on induction of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), pro-inflammatory cytokines (interleukin-6 (IL-6) and tumor necrosis factor- α (TNF- α )) and nuclear factor-kappa B (NF- κ B) as well as mitogen-activated protein kinases (MAPKs) in lipopolysaccharide-(LPS-) induced Raw 264.7 cells and on paw edema in rats. Treatment with PWS (0.5, 0.75, and 1 mg/mL) resulted in inhibited levels of expression of LPS-induced COX-2, iNOS, NF- κ B, and MAPKs as well as production of prostaglandin E2 (PGE2), nitric oxide (NO), IL-6, and TNF- α induced by LPS. Our results demonstrate that PWS possesses anti-inflammatory activities via decreasing production of pro-inflammatory mediators through suppression of the signaling pathways of NF- κ B and MAPKs in LPS-induced macrophage cells. More importantly, results of the carrageenan-(CA-) induced paw edema demonstrate an anti-edema effect of PWS. In addition, it is considered that PWS also inhibits the acute edematous inflammations through suppression of mast cell degranulations and inflammatory mediators, including COX-2, iNOS and TNF- α . Thus, our findings may provide scientific evidence to explain the anti-inflammatory properties of PWS in vitro and in vivo.
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Registered trials
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