ArticleEvidence-based complementary and alternative medicine : eCAM2013
Metabolomic study of collagen-induced arthritis in rats and the interventional effects of huang-lian-jie-du-tang, a traditional chinese medicine.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 65 citations in OpenAlex.
- Analysis of fecal microbiome and metabolome changes in goats with pregnant toxemia.BMC veterinary research · 2024Article
- Integrated metabolomics and network analysis reveal changes in lipid metabolisms of tripterygium glycosides tablets in rats with collagen-induced arthritis.Computational and structural biotechnology journal · 2023Article
- Therapeutic potential of Coptis chinensis for arthritis with underlying mechanisms.Frontiers in pharmacology · 2023Review
- Analysis of the saliva metabolic signature in patients with primary Sjögren's syndrome.PloS one · 2022Article
- Lingzhi and San-Miao-San with hyaluronic acid gel mitigate cartilage degeneration in anterior cruciate ligament transection induced osteoarthritis.Journal of orthopaedic translation · 2021Article
- Huanglian Jiedu Decoction ameliorates DSS-induced colitis in mice via the JAK2/STAT3 signalling pathway.Chinese medicine · 2020Article
- Traditional Oriental Medicines and Alzheimer's Disease.Aging and disease · 2019Review
- Huang-Lian Jie-Du decoction: a review on phytochemical, pharmacological and pharmacokinetic investigations.Chinese medicine · 2019Review
- LC-MS-based serum metabolomics reveals a distinctive signature in patients with rheumatoid arthritis.Clinical rheumatology · 2018Article
- Antiplatelet and Antithrombotic Activity of a Traditional Medicine, Hwangryunhaedok-Tang.Frontiers in pharmacology · 2018Article
- Metabolic fingerprinting of joint tissue of collagen-induced arthritis (CIA) rat: In vitro, high resolution NMR (nuclear magnetic resonance) spectroscopy based analysis.EXCLI journal · 2018Article
- Origin and Formation Mechanism Investigation of Compound Precipitation from the Traditional Chinese Prescription Huang-Lian-Jie-Du-Tang by Isothermal Titration Calorimetry.Molecules (Basel, Switzerland) · 2017Article
- Pharmacokinetic-Pharmacodynamic Analysis on Inflammation Rat Model after Oral Administration of Huang Lian Jie Du Decoction.PloS one · 2016Article
- Metabolomic Study on the Preventive Effect of Patrinia scabiosaefolia Fisch on Multipathogen Induced Pelvic Inflammatory Disease in Rats.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Bioinformatics analysis for the antirheumatic effects of huang-lian-jie-du-tang from a network perspective.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Protective Effects of Huang-Lian-Jie-Du-Tang against Polymicrobial Sepsis Induced by Cecal Ligation and Puncture in Rats.Evidence-based complementary and alternative medicine : eCAM · 2013Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Huang-Lian-Jie-Du-Tang (HLJDT) is a traditional Chinese medicine (TCM) with anti-inflammatory activity. The present study used a metabolomic approach based on LC-Q-TOF-MS to profile rheumatoid-arthritis- (RA-) related metabolic changes and to investigate the interventional mechanisms of HLJDT in collagen-induced arthritis rats. Forty male Wistar rats were randomly divided into five groups: (1) a model group, (2) a normal control group, (3) a dexamethasone group, (4) a HLJDT group, and (5) a group that received 13 components of HLJDT. Plasma samples were collected 8, 15, and 22 days after the rats were injected with bovine type II collagen. By combining variable importance in the projection values with partial least squares discriminant analysis, 18 potential biomarkers were identified in the plasma samples. The biomarkers were primarily involved in glycerophospholipid metabolism, fatty acid metabolism, tryptophan metabolism, linoleic acid metabolism, phenylalanine metabolism, purine metabolism, arachidonic acid metabolism, and bile acid biosynthesis. Using the potential biomarkers as a screening index, the results suggest that HLJDT can potentially reverse the process of RA by partially regulating fatty acid oxidation and arachidonic acid metabolism. This study demonstrates that a metabolomic strategy is useful for identifying potential RA biomarkers and investigating the underlying mechanisms of a TCM in RA treatment.
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Registered trials
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