ArticleEvidence-based complementary and alternative medicine : eCAM2013
Extract of Wax Gourd Peel Prevents High-Fat Diet-Induced Hyperlipidemia in C57BL/6 Mice via the Inhibition of the PPARγ Pathway.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Genome-Wide Identification of theBiology · 2025Article
- Map-based cloning revealed BhAPRR2 gene regulating the black peel formation of mature fruit in wax gourd (Benincasa hispida).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- The GA and ABA signaling is required for hydrogen-mediated seed germination in wax gourd.BMC plant biology · 2024Article
- Genome-wide identification of bZIP gene family and expression analysis of BhbZIP58 under heat stress in wax gourd.BMC plant biology · 2023Article
- Comparative transcriptome provides insights into gene regulation network associated with the resistance toFrontiers in plant science · 2023Article
- Ethnopharmacology, phytochemistry and pharmacology ofChinese herbal medicines · 2023Review
- Genome-Wide Identification of theInternational journal of molecular sciences · 2022Article
- Development and Application of InDel Markers Linked to Fruit-Shape and Peel-Colour Genes in Wax Gourd.Genes · 2022Article
- Genome-Wide Identification ofGenes · 2022Article
- Genetic mapping and genome-wide association study identifyFrontiers in plant science · 2022Article
- Isolation of Anti-Diabetic Active Compounds from Benincasae Exocarpium and Development of Simultaneous Analysis by HPLC-PDA.Molecules (Basel, Switzerland) · 2021Article
- Fine mapping and identification of the candidate gene BFS for fruit shape in wax gourd (Benincasa hispida).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Review
- The wax gourd genomes offer insights into the genetic diversity and ancestral cucurbit karyotype.Nature communications · 2019Article
- Hypolipidemic effects of total flavonoide extracted from the leaves ofIranian journal of basic medical sciences · 2017Article
- MDG-1, a Potential Regulator of PPARα and PPARγ, Ameliorates Dyslipidemia in Mice.International journal of molecular sciences · 2017Article
- Dietary restriction reduces blood lipids and ameliorates liver function of mice with hyperlipidemia.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017Article
- Article
- Bardoxolone Methyl Prevents High-Fat Diet-Induced Colon Inflammation in Mice.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
- Supplementation with the extract of schisandrae fructus pulp, seed, or their combination influences the metabolism of lipids and glucose in mice fed with normal and hypercholesterolemic diet.Evidence-based complementary and alternative medicine : eCAM · 2014Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wax gourd is a popular vegetable in East Asia. In traditional Chinese medicine, wax gourd peel is used to prevent and treat metabolic diseases such as hyperlipidemia, hyperglycemia, obesity, and cardiovascular disease. However, there is no experimental evidence to support these applications. Here, we examined the effect of the extract of wax gourd peel (EWGP) on metabolic disorders in diet-induced C57BL/6 obese mice. In the preventive experiment, EWGP blocked body weight gain and lowered serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), liver TG and TC contents, and fasting blood glucose in mice fed with a high-fat diet. In the therapeutic study, we induced obesity in the mice and treated with EWGP for two weeks. We found that EWGP treatment reduced serum and liver triglyceride (TG) contents and fasting blood glucose and improved glucose tolerance in the mice. Reporter assay and gene expression analysis showed that EWGP could inhibit peroxisome proliferator-activated receptor γ (PPAR γ ) transactivities and could decrease mRNA levels of PPAR γ and its target genes. We also found that HMG-CoA reductase (HMGCR) was downregulated in the mouse liver by EWGP. Our data suggest that EWGP lowers hyperlipidemia of C57BL/6 mice induced by high-fat diet via the inhibition of PPAR γ and HMGCR signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.