ArticleEvidence-based complementary and alternative medicine : eCAM2013
Quercetin Preserves β -Cell Mass and Function in Fructose-Induced Hyperinsulinemia through Modulating Pancreatic Akt/FoxO1 Activation.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Potential of Quercetin as a Promising Therapeutic Agent Against Type 2 Diabetes.Molecules (Basel, Switzerland) · 2025Review
- Fructose metabolism and its roles in metabolic diseases, inflammatory diseases, and cancer.Molecular biomedicine · 2025Review
- Mechanisms of action of natural products on type 2 diabetes.World journal of diabetes · 2023Review
- Binding mechanism and biological effects of flavone DYRK1A inhibitors for the design of new antidiabetics.Scientific reports · 2023Article
- Controlled SPION-Exosomes Loaded with Quercetin Preserves Pancreatic Beta Cell Survival and Function in Type 2 Diabetes Mellitus.International journal of nanomedicine · 2023Article
- Intracellular ATP Signaling Contributes to FAM3A-Induced PDX1 Upregulation in Pancreatic Beta Cells.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2022Article
- Quercetin supplementation alters adipose tissue and hepatic transcriptomes and ameliorates adiposity, dyslipidemia, and glucose intolerance in adult male rats.Frontiers in nutrition · 2022Article
- Physiological effects of nutrients on insulin release by pancreatic beta cells.Molecular and cellular biochemistry · 2021Review
- (-)-Leucophyllone, a Tirucallane Triterpenoid fromPlants (Basel, Switzerland) · 2021Article
- Antidiabetic Medicinal Plants Used in Democratic Republic of Congo: A Critical Review of Ethnopharmacology and Bioactivity Data.Frontiers in pharmacology · 2021Review
- Effects of Polyphenols on Insulin Resistance.Nutrients · 2020Review
- Administration of mulberry leaves maintains pancreatic β-cell mass in obese/type 2 diabetes mellitus mouse model.BMC complementary medicine and therapies · 2020Article
- Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats.Scientific reports · 2020Article
- Estimated daily quercetin intake and association with the prevalence of type 2 diabetes mellitus in Chinese adults.European journal of nutrition · 2019Article
- Differential Impact of Flavonoids on Redox Modulation, Bioenergetics, and Cell Signaling in Normal and Tumor Cells: A Comprehensive Review.Antioxidants & redox signaling · 2018Review
- Beneficial effects of a red wine polyphenol extract on high-fat diet-induced metabolic syndrome in rats.European journal of nutrition · 2017Article
- High Dietary Fructose: Direct or Indirect Dangerous Factors Disturbing Tissue and Organ Functions.Nutrients · 2017Review
- Reduced islet function contributes to impaired glucose homeostasis in fructose-fed mice.American journal of physiology. Endocrinology and metabolism · 2017Article
- Article
- Flavonols in the Prevention of Diabetes-induced Vascular Dysfunction.Journal of cardiovascular pharmacology · 2015Review
Corrections and comments
- Retracted
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fructose-induced hyperinsulinemia is associated with insulin compensative secretion and predicts the onset of type 2 diabetes. In this study, we investigated the preservation of dietary flavonoid quercetin on pancreatic β -cell mass and function in fructose-treated rats and INS-1 β -cells. Quercetin was confirmed to reduce serum insulin and leptin levels and blockade islet hyperplasia in fructose-fed rats. It also prevented fructose-induced β -cell proliferation and insulin hypersecretion in INS-1 β -cells. High fructose increased forkhead box protein O1 (FoxO1) expressions in vivo and in vitro, which were reversed by quercetin. Quercetin downregulated Akt and FoxO1 phosphorylation in fructose-fed rat islets and increased the nuclear FoxO1 levels in fructose-treated INS-1 β -cells. The elevated Akt phosphorylation in fructose-treated INS-1 β -cells was also restored by quercetin. Additionally, quercetin suppressed the expression of pancreatic and duodenal homeobox 1 (Pdx1) and insulin gene (Ins1 and Ins2) in vivo and in vitro. In fructose-treated INS-1 β -cells, quercetin elevated the reduced janus kinase 2/signal transducers and activators of transcription 3 (Jak2/Stat3) phosphorylation and suppressed the increased suppressor of cytokine signaling 3 (Socs3) expression. These results demonstrate that quercetin protects β -cell mass and function under high-fructose induction through improving leptin signaling and preserving pancreatic Akt/FoxO1 activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.