ArticleEvidence-based complementary and alternative medicine : eCAM2013
Eugenia uniflora L. Essential Oil as a Potential Anti-Leishmania Agent: Effects on Leishmania amazonensis and Possible Mechanisms of Action.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Activity of the genusFrontiers in pharmacology · 2022Pooled it
- Unveiling Chemical Profile and Insecticidal Potential of Essential Oils from Leaves of SevenPlants (Basel, Switzerland) · 2026Article
- Antifungal Potential of Essential Oil Chemotypes of Eugenia uniflora Against Phytopathogens.Chemistry & biodiversity · 2026Article
- Larvicidal, oviposition inhibition, electrophysiological, histological, and docking activity ofFrontiers in pharmacology · 2026Article
- Toward Understanding the Anticancer Activity of the Phytocompounds fromAdvances and applications in bioinformatics and chemistry : AABC · 2024Article
- Antibacterial Activity and Antibacterial Mechanism of Lemon Verbena Essential Oil.Molecules (Basel, Switzerland) · 2023Article
- Article
- Essentials Oils from BrazilianBiomolecules · 2020Review
- The Antitumor Efficacy ofBioMed research international · 2020Review
- Ethnopharmacology Study of Plants from Atlantic Forest with Leishmanicidal Activity.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses.Oxidative medicine and cellular longevity · 2019Review
- Influence of Eugenia uniflora Extract on Adhesion to Human Buccal Epithelial Cells, Biofilm Formation, and Cell Surface Hydrophobicity of Candida spp. from the Oral Cavity of Kidney Transplant Recipients.Molecules (Basel, Switzerland) · 2018Article
- Gallic and ellagic acids: two natural immunomodulator compounds solve infection of macrophages by Leishmania major.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Chemical Composition, Antifungal and Antioxidant Activities of Hedyosmum brasiliense Mart. ex Miq. (Chloranthaceae) Essential Oils.Medicines (Basel, Switzerland) · 2017Article
- Article
- Article
- Effect of the crude extract of Eugenia uniflora in morphogenesis and secretion of hydrolytic enzymes in Candida albicans from the oral cavity of kidney transplant recipients.BMC complementary and alternative medicine · 2015Article
- Therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products.Memorias do Instituto Oswaldo Cruz · 2015Article
- Antileishmanial Potential of Tropical Rainforest Plant Extracts.Medicines (Basel, Switzerland) · 2014Article
- Chemical constituents and toxicological studies of leaves from Mimosa caesalpiniifolia Benth., a Brazilian honey plant.Pharmacognosy magazine · 2014Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eugenia uniflora L. is a member of the Myrtaceae family and is commonly known as Brazilian cherry tree. In this study, we evaluated the chemical composition of Eugenia uniflora L. essential oil (EuEO) by using gas chromatography-mass spectrometry (GC-MS) and assessed its anti-Leishmania activity. We also explored the potential mechanisms of action and cytotoxicity of EuEO. Thirty-two compounds were identified, which constituted 92.65% of the total oil composition. The most abundant components were sesquiterpenes (91.92%), with curzerene (47.3%), γ -elemene (14.25%), and trans- β -elemenone (10.4%) being the major constituents. The bioactivity shown by EuEO against promastigotes (IC50, 3.04 μ g·mL(-1)) and amastigotes (IC50, 1.92 μ g·mL(-1)) suggested significant anti-Leishmania activity. In the cytotoxicity determination, EuEO was 20 times more toxic to amastigotes than to macrophages. Hemolytic activity was 63.22% at the highest concentration tested (400 μ g·mL(-1)); however, there appeared to be no toxicity at 50 μ g·mL(-1). While the data show that EuEO activity is not mediated by nitric oxide production, they do suggest that macrophage activation may be involved in EuEO anti-Leishmania activity, as evidenced by increases in both the phagocytic capacity and the lysosomal activity. More studies are needed to determine in vivo activity as well as additional mechanisms of the anti-Leishmania activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.