ArticleJournal of toxicology2013
Epigenetically mediated pathogenic effects of phenanthrene on regulatory T cells.
Article in Journal of toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- New insights into coordinated regulation of AHR promoter transcription; molecular mechanisms and therapeutic targets.International journal of biological sciences · 2025Review
- Serum Allergen-Specific Immunoglobulin E in Cats with Inflammatory Bronchial Disease.Animals : an open access journal from MDPI · 2023Article
- Association of chronic kidney disease with exposure to polycyclic aromatic hydrocarbons in the US population.Environmental science and pollution research international · 2022Article
- Relationship between miR-203a inhibition and oil-induced toxicity in early life stage zebrafish (Toxicology reports · 2022Article
- Air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis.Environmental science and pollution research international · 2021Review
- The Potential Relationship Between Environmental Endocrine Disruptor Exposure and the Development of Endometriosis and Adenomyosis.Frontiers in physiology · 2021Review
- Epigenetic Regulations of AhR in the Aspect of Immunomodulation.International journal of molecular sciences · 2020Review
- Polyaromatic hydrocarbons in pollution: a heart-breaking matter.The Journal of physiology · 2020Review
- Filaggrin null mutations are associated with altered circulating Tregs in atopic dermatitis.Journal of cellular and molecular medicine · 2019Article
- Polycyclic Aromatic Hydrocarbons: A Critical Review of Environmental Occurrence and Bioremediation.Environmental management · 2017Article
- Spatial and Temporal Distribution of Polycyclic Aromatic Hydrocarbons and Elemental Carbon in Bakersfield, California.Air quality, atmosphere, & health · 2016Article
- Phenanthrene exposure induces cardiac hypertrophy via reducing miR-133a expression by DNA methylation.Scientific reports · 2016Article
- Ambient polycyclic aromatic hydrocarbons and pulmonary function in children.Journal of exposure science & environmental epidemiology · 2015Article
- Can exposure to environmental chemicals increase the risk of diabetes type 1 development?BioMed research international · 2015Review
- Environmental effects on immune responses in patients with atopy and asthma.The Journal of allergy and clinical immunology · 2014Review
- Polycyclic aromatic hydrocarbons, tobacco smoke, and epigenetic remodeling in asthma.Immunologic research · 2014Review
- Epigenetic regulation: the interface between prenatal and early-life exposure and asthma susceptibility.Environmental and molecular mutagenesis · 2014Review
- Mapping and modeling airborne urban phenanthrene distribution using vegetation biomonitoring.Atmospheric environment (Oxford, England : 1994) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Phenanthrene (Phe), a polycyclic aromatic hydrocarbon (PAH), is a major constituent of urban air pollution. There have been conflicting results regarding the role of other AhR ligands 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) and 6-formylindolo [3,2-b]carbazole (FICZ) in modifying regulatory T cell populations (Treg) or T helper (Th)17 differentiation, and the effects of Phe have been understudied. We hypothesized that different chemical entities of PAH induce Treg to become either Th2 or Th17 effector T cells through epigenetic modification of FOXP3. To determine specific effects on T cell populations by phenanthrene, primary human Treg were treated with Phe, TCDD, or FICZ and assessed for function, gene expression, and phenotype. Methylation of CpG sites within the FOXP3 locus reduced FOXP3 expression, leading to impaired Treg function and conversion of Treg into a CD4(+)CD25(lo) Th2 phenotype in Phe-treated cells. Conversely, TCDD treatment led to epigenetic modification of IL-17A and conversion of Treg to Th17 T cells. These findings present a mechanism by which exposure to AhR-ligands mediates human T cell responses and begins to elucidate the relationship between environmental exposures, immune modulation, and initiation of human disease.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.