ArticleTheScientificWorldJournal2013
Genome-wide analysis of DNA methylation in human amnion.
Article in TheScientificWorldJournal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Racial and ethnic representation in epigenomic studies of preterm birth: a systematic review.Epigenomics · 2021Pooled it
- A Systematic Review of DNA Methylation and Preterm Birth in African American Women.Biological research for nursing · 2017Pooled it
- Gestational tissue transcriptomics in term and preterm human pregnancies: a systematic review and meta-analysis.BMC medical genomics · 2015Pooled it
- Conservation of gene expression patterns between the amniotic and nasal epithelium at birth.ERJ open research · 2025Article
- Programming of the respiratory epitheliummedRxiv : the preprint server for health sciences · 2025Article
- Cost-effective promoter methylation analysis via target long-read bisulfite sequencing: a case study in severe preterm birth.BMC medical genomics · 2025Article
- Regulation of term and preterm labor: genetics and epigenetics.Frontiers in genetics · 2025Article
- Airway epithelium respiratory illnesses and allergy (AERIAL) birth cohort: study protocol.Frontiers in allergy · 2024Article
- Oxytocin receptor DNA methylation is associated with exogenous oxytocin needs during parturition and postpartum hemorrhage.Communications medicine · 2023Article
- Article
- Multi-level hypothalamic neuromodulation of self-regulation and cognition in preterm infants: Towards a control systems model.Comprehensive psychoneuroendocrinology · 2022Review
- An epigenetic rheostat of experience: DNA methylation ofComprehensive psychoneuroendocrinology · 2021Review
- Elevated methylation of the vault RNA2-1 promoter in maternal blood is associated with preterm birth.BMC genomics · 2021Article
- Epigenetic biomarkers and preterm birth.Environmental epigenetics · 2020Review
- Functional Genomics of Healthy and Pathological Fetal Membranes.Frontiers in physiology · 2020Review
- Fetal Membrane Epigenetics.Frontiers in physiology · 2020Review
- Comparison of DNA methylation profiles associated with spontaneous preterm birth in placenta and cord blood.BMC medical genomics · 2019Article
- DNA methylation profiling of acute chorioamnionitis-associated placentas and fetal membranes: insights into epigenetic variation in spontaneous preterm births.Epigenetics & chromatin · 2018Article
- Differential expression and methylation of integrin subunit alpha 11 and thrombospondin in the amnion of preterm birth.Obstetrics & gynecology science · 2018Article
- Genome-wide alteration in DNA hydroxymethylation in the sperm from bisphenol A-exposed men.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
The amnion is a specialized tissue in contact with the amniotic fluid, which is in a constantly changing state. To investigate the importance of epigenetic events in this tissue in the physiology and pathophysiology of pregnancy, we performed genome-wide DNA methylation profiling of human amnion from term (with and without labor) and preterm deliveries. Using the Illumina Infinium HumanMethylation27 BeadChip, we identified genes exhibiting differential methylation associated with normal labor and preterm birth. Functional analysis of the differentially methylated genes revealed biologically relevant enriched gene sets. Bisulfite sequencing analysis of the promoter region of the oxytocin receptor (OXTR) gene detected two CpG dinucleotides showing significant methylation differences among the three groups of samples. Hypermethylation of the CpG island of the solute carrier family 30 member 3 (SLC30A3) gene in preterm amnion was confirmed by methylation-specific PCR. This work provides preliminary evidence that DNA methylation changes in the amnion may be at least partially involved in the physiological process of labor and the etiology of preterm birth and suggests that DNA methylation profiles, in combination with other biological data, may provide valuable insight into the mechanisms underlying normal and pathological pregnancies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.