ArticleTheScientificWorldJournal2013
DNA damage sensor γ -H2AX is increased in preneoplastic lesions of hepatocellular carcinoma.
Article in TheScientificWorldJournal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
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- Evaluation of Systemic Injury in Calves with Rotavirus-Induced Diarrhea Using Sensitive Biomarkers and Immunopathology.International journal of molecular sciences · 2025Article
- An overview of risk assessment and monitoring of malignant transformation in cirrhotic nodules.Therapeutic advances in gastroenterology · 2024Review
- Tumor Promoting Effects of Sulforaphane on Diethylnitrosamine-Induced Murine Hepatocarcinogenesis.International journal of molecular sciences · 2022Article
- Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice.Cell death & disease · 2022Article
- Epigenetic remodelling in human hepatocellular carcinoma.Journal of experimental & clinical cancer research : CR · 2022Review
- Metronidazole enhances steatosis-related early-stage hepatocarcinogenesis in high fat diet-fed rats through DNA double-strand breaks and modulation of autophagy.Environmental science and pollution research international · 2022Article
- A necroptosis -related signature for predicting prognosis and immunotherapy in hepatocellular carcinoma.Frontiers in genetics · 2022Article
- Impact of DNA double-strand breaks on pancreaticobiliary maljunction carcinogenesis.Diagnostic pathology · 2021Article
- CDCA8, targeted by MYBL2, promotes malignant progression and olaparib insensitivity in ovarian cancer.American journal of cancer research · 2021Article
- Identification of Gene Signature as Diagnostic and Prognostic Blood Biomarker for Early Hepatocellular Carcinoma Using Integrated Cross-Species Transcriptomic and Network Analyses.Frontiers in genetics · 2021Article
- Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Replenishment of Hepatitis B Virus cccDNA Pool Is Restricted by Baseline Expression of Host Restriction Factors In Vitro.Microorganisms · 2019Article
- ATM and ATR Expression Potentiates HBV Replication and Contributes to Reactivation of HBV Infection upon DNA Damage.Viruses · 2019Article
- Orthologous CRISPR/Cas9 systems for specific and efficient degradation of covalently closed circular DNA of hepatitis B virus.Cellular and molecular life sciences : CMLS · 2019Article
- Splicing events in the control of genome integrity: role of SLU7 and truncated SRSF3 proteins.Nucleic acids research · 2019Article
- Review
- Review
- Splicing alterations contributing to cancer hallmarks in the liver: central role of dedifferentiation and genome instability.Translational gastroenterology and hepatology · 2018Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhosphorylated histone H2AX ( γ -H2AX) is a potential regulator of DNA repair and is a useful tool for detecting DNA damage. To evaluate the clinical usefulness of γ -H2AX in hepatocellular carcinoma (HCC), we measured the level of γ -H2AX in HCC, dysplastic nodule, and nontumorous liver diseases.
methodsThe level of γ -H2AX was measured by immunohistochemistry in fifty-eight HCC, 18 chronic hepatitis, 22 liver cirrhosis, and 19 dysplastic nodules. Appropriate cases were also examined by fluorescence analysis and western blotting. results: All cases with chronic liver disease showed increased levels of γ -H2AX expression. In 40 (69.9%) of 58 cases with HCC, the labeling index (LI) of γ -H2AX was above 50% and was inversely correlated with the histological grade. Mean γ -H2AX LI was the highest in dysplastic nodule (74.1 ± 22.1%), which was significantly higher than HCC (P < 0.005). Moreover, γ -H2AX was significantly increased in nontumorous tissues of HCC as compared with liver cirrhosis without HCC (62.5 ± 24.7%, from 5.1 to 96.0%, P < 0.005).
conclusionsγ -H2AX was increased in the preneoplastic lesions of HCC and might be a useful biomarker for predicting the risk of HCC.
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