Evidence map›Paper›PMID 23533227›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2013

Effects of testosterone and progressive resistance exercise in healthy, highly functioning older men with low-normal testosterone levels.

Kerry L Hildreth, Daniel W Barry, Kerrie L Moreau, Joseph Vande Griend, Randall B Meacham, Tammie Nakamura, Pamela Wolfe, Wendy M Kohrt, J Mark Ruscin, John Kittelson and 3 more

Registry-linked trialOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03282682 (Strength Training as a Supplemental Therapy of Androgen Deficiency of the Aging Male), which is not on this map. Cited by 62 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 13 pooled it
7.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03282682 nacompletednot on this mapstarted 2017, after this paper: background citation

Strength Training as a Supplemental Therapy of Androgen Deficiency of the Aging Male (ADAM)

TypeinterventionalSponsorComenius UniversityRan2017 to 2019Enrolled22ConditionsHypogonadism, Male, Physical Activity, Testosterone DeficiencyArmsStrength training
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 13 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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  9. Delaying and reversing frailty: a systematic review of primary care interventions.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Kerry L HildrethDepartment of Medicine, University of Colorado School of Medicine, Aurora, Colorado 80045, USA. kerry.hildreth@ucdenver.edu
Daniel W Barry
Kerrie L Moreau
Joseph Vande Griend
Randall B Meacham
Tammie Nakamura
Pamela Wolfe
Wendy M Kohrt
J Mark Ruscin
John Kittelson
M Elaine Cress
Robert Ballard
Robert S Schwartz
University of Warwick · GBUniversity of Lübeck · DE

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 1995 to 2026
$32.6M
University of Colorado Aging Training GrantT32AG000279 · NIA · UNIVERSITY OF COLORADO DENVER · PI Kerrie Moreau · 2001 to 2026
$10.1M
Testosterone Supplementation and Exercise in Elderly MenR01AG019339 · NIA · UNIVERSITY OF COLORADO DENVER · PI SCHWARTZ, ROBERT S · 2004 to 2008
$4.1M
NCATS NIH HHS UL1 TR001082NIA NIH HHS R01 AG019339NIA NIH HHS T32 AG000279NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

contextAging in men is associated with reduced testosterone (T) levels and physiological changes leading to frailty, but the benefits of T supplementation are inconclusive.

objectiveWe studied the effects of T supplementation with and without progressive resistance training (PRT) on functional performance, strength, and body composition. DESIGN, SETTING, AND

participantsWe recruited 167 generally healthy community-dwelling older men (66 ± 5 years) with low-normal baseline total T levels (200-350 ng/dL).

interventionSubjects were randomized to placebo or transdermal T gel [2 doses targeting either a lower (400-550 ng/dL) or higher (600-1000 ng/dL) T range] and to either PRT or no exercise for 12 months.

main outcome measureThe primary outcome was functional performance, whereas secondary outcomes were strength and body composition.

resultsA total of 143 men completed the study. At 12 months, total T was 528 ± 287 ng/dL in subjects receiving any T and 287 ± 65 ng/dL in the placebo group. In the PRT group, function and strength were not different between T- and placebo-treated subjects, despite greater improvements in fat mass (P = .04) and fat-free mass (P = .01) with T. In the non-PRT group, T did not improve function but improved fat mass (P = .005), fat-free mass (P = .03), and upper body strength (P = .03) compared with placebo. There were fewer cardiovascular events in the T-treated groups compared with placebo.

conclusionsT supplementation was well tolerated and improved body composition but had no effect on functional performance. T supplementation improved upper body strength only in nonexercisers compared with placebo.

Indexed as

AgingHormone Replacement TherapyResistance TrainingActivities of Daily LivingAgedBody CompositionCardiovascular DiseasesCombined Modality TherapyDose-Response Relationship, DrugGeriatric AssessmentHumansLost to Follow-UpMaleMuscle StrengthPatient CompliancePatient DropoutsSex Hormone-Binding GlobulinTestosterone

Identifiers

PMID23533227
PMCPMC3644594
OpenAlexW2027596334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.