ArticleInternational journal of medical sciences2013
Fetal hypoxia results in programming of aberrant angiotensin ii receptor expression patterns and kidney development.
Article in International journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Early-life exposures and long-term health: adverse gestational environments and the programming of offspring renal and vascular disease.American journal of physiology. Renal physiology · 2024Review
- Perinatal intermittent hypoxia increases early susceptibility to ANG II-induced hypertension in adult male but not in female Sprague-Dawley rats.American journal of physiology. Renal physiology · 2023Article
- Increased Arterial Responsiveness to Angiotensin II in Mice Conceived by Assisted Reproductive Technologies.International journal of molecular sciences · 2022Article
- Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress.Nature communications · 2021Article
- Prenatal hypoxia increases susceptibility to kidney injury.PloS one · 2020Article
- The novel and critical role of von Hippel-Lindau in nephron formation.Annals of translational medicine · 2019Article
- Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation.Journal of the American Society of Nephrology : JASN · 2019Article
- Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.The Journal of physiology · 2019Article
- Inherited risk plus prenatal insult caused malignant dysfunction in mesenteric arteries in adolescent SHR offspring.PloS one · 2019Article
- Gestational Hypoxia and Developmental Plasticity.Physiological reviews · 2018Review
- Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development.Kidney international · 2017Article
- The effect of resveratrol on angiotensin II levels and the rate of transcription of its receptors in the rat cardiac hypertrophy model.The journal of physiological sciences : JPS · 2017Article
- Ovine uterine space restriction causes dysregulation of the renin-angiotensin system in fetal kidneys.Biology of reproduction · 2017Article
- Effect of Hypoxia on the Differentiation and the Self-Renewal of Metanephrogenic Mesenchymal Stem Cells.Stem cells international · 2017Article
- Ketamine suppresses hypoxia-induced inflammatory responses in the late-gestation ovine fetal kidney cortex.The Journal of physiology · 2016Article
- Chronic hypoxia in pregnancy affected vascular tone of renal interlobar arteries in the offspring.Scientific reports · 2015Article
- Prenatal exposure to hypoxia induced Beclin 1 signaling-mediated renal autophagy and altered renal development in rat fetuses.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
- Mid- to late term hypoxia in the mouse alters placental morphology, glucocorticoid regulatory pathways and nutrient transporters in a sex-specific manner.The Journal of physiology · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
aimsThe present study tested the hypothesis that fetal hypoxia adversely affects kidney development in fetal and offspring rats and alter the expression patterns of angiotensin II type 1 (AT1R) and type 2 (AT2R) receptors.
methodsTime-dated pregnant rats were divided between normoxic and hypoxic (10.5% O2 last period of gestation) groups. Protein expression, in the offspring, was determined using western blot.
resultsHypoxic treatment significantly decreased body and kidney weight in 21-day fetuses (E21) and 7-day neonates (P7). In 3-month-old offspring there were no significant differences in body and kidney weight between hypoxic and control animals. Fetal hypoxia had no effect on kidney AT1R density in E21 or P7, but significantly decreased kidney AT1R protein and mRNA abundance in both male and female adults. In contrast, kidney AT2R density was not affected by fetal hypoxia throughout the developmental stages studied. The hypoxia-mediated reduction of nephron numbers was progressively from P7 worsened into the adulthood with females affected more than males.
conclusionThe results suggest that fetal hypoxia causes programming of aberrant kidney development and accelerates the aging process of the kidney during the postnatal development, which may contribute to an increased risk of cardiovascular disease.
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