Trial reportWorld journal of surgery2013
Does preoperative 25-hydroxyvitamin D status significantly affect the calcium kinetics after total thyroidectomy?
Trial report in World journal of surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed.
- Impact of Preoperative Calcium and Magnesium Supplementation on Quality of Life and Hypocalcemia Post-Thyroidectomy.Endocrinology, diabetes & metabolism · 2026Trial
- The effect of preoperative vitamin D values on hypocalcemia after total thyroidectomy.Turkish journal of surgery · 2024Article
- Does Vitamin D Deficiency Really Increase the Risk of Post-surgical Hypoparathyroidism?Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Preoperative and postoperative optimisation of patients undergoing thyroid surgery: a multicentre quality improvement project at Barts Health NHS Trust.BMJ open quality · 2023Article
- Effect of Preoperative Vitamin D Deficiency on Hypocalcemia in Patients with Acute Hypoparathyroidism after Thyroidectomy.International journal of endocrinology · 2020Article
- Preoperative vitamin D deficiency is a risk factor for postoperative hypocalcemia in patients undergoing total thyroidectomy: retrospective cohort study.Sao Paulo medical journal = Revista paulista de medicina · 2019Article
- Can preoperative vitamin D deficiency predict postoperative hypoparathyroidism following thyroid surgery?Langenbeck's archives of surgery · 2019Article
- [Prophylaxis of postoperative hypoparathyroidism by intravenous administration of calcium gluconate].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018Article
- Incidence, prevalence and risk factors for post-surgical hypocalcaemia and hypoparathyroidism.Gland surgery · 2017Review
- A Case of "Late" Postsurgical Hypoparathyroidism.Case reports in endocrinology · 2017Article
- Vitamin D level is not a predictor of hypocalcemia after total thyroidectomy.Langenbeck's archives of surgery · 2015Observational
- [Surgical assessment of complications after thyroid gland operations].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2015Review
- Incidence and predictors of post-thyroidectomy hypocalcaemia in a tertiary endocrine surgical unit.Annals of the Royal College of Surgeons of England · 2014Article
- Preoperative vitamin D level as a post-total thyroidectomy hypocalcemia predictor: a prospective study.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough previous studies have suggested that low preoperative 25-hydroxyvitamin D (25-OHD) is a risk factor for hypocalcemia after total thyroidectomy, the impact of preoperative 25-OHD on calcium (Ca)/parathyroid hormone (PTH) kinetics in the immediate postoperative period remains unclear. The study compared the postoperative Ca/PTH kinetics between different preoperative 25-OHD levels. PATIENTS: A total of 281 patients who underwent a total thyroidectomy were analyzed. Serum Ca was measured preoperatively within 1 h after surgery (Ca-D0) and on the following morning (Ca-D1). Preoperative 25-OHD was also measured after overnight fasting while postoperative PTH was checked at skin closure on day 0 (PTH-D0) and on the following morning on day 1 (PTH-D1). The Ca/PTH kinetics were compared between three groups (group I: preoperative 25-OHD < 10 ng/mL; group II: 25-OHD = 10-20 ng/mL; group III: 25-OHD > 20 ng/mL).
resultsGroup I had significantly lower preoperative Ca (p = 0.016) and Ca-D0 (p = 0.036) but higher PTH-D1 (p = 0.015) than groups II and III. PTH-D0, Ca-D1, and the rate of clinically significant hypocalcemia were similar in the three groups. Group I had a significantly smaller Ca drop (-0.02 vs. 0.01 and 0.02 mmol/L, p = 0.011) and a tendency for a significantly smaller PTH drop (0.4 vs. 0.5 and 1.0 pmol/L, p = 0.073) than groups II and III. PTH-D1 (OR = 1.550) and 25-OHD (OR = 0.958) were independent factors for Ca drop from day 0 to day 1.
conclusionsAlthough group I began with lower serum Ca, those patients tended to have a greater PTH response to Ca drop and so preoperative 25-OHD did not significantly affect the overall Ca kinetics from preoperative to day 1.
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