ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2013
Contribution of genetic background, traditional risk factors, and HIV-related factors to coronary artery disease events in HIV-positive persons.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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30 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Risk of cardiovascular disease associated with exposure to abacavir among individuals with HIV: A systematic review and meta-analyses of results from 17 epidemiologic studies.International journal of antimicrobial agents · 2018Pooled it
- Association Between Patatin-Like Phospholipase Do-Main-Containing Protein-3 Variant and Cardiovascular Disease Risk in People Living With HIV on Antiretroviral Therapy in Taiwan: A Cross-Sectional Study.Health science reports · 2026Article
- Genomic risk prediction of type 2 diabetes in people living with and without HIV.Scientific reports · 2026Article
- Association of a polygenic risk score with low trauma fractures in people with HIV - The swiss HIV cohort study.PloS one · 2026Article
- The potential role of trained immunity in HIV-associated atherosclerotic cardiovascular disease: mechanisms and therapeutic implications.Frontiers in immunology · 2026Review
- Leukocyte count and new-onset diabetes mellitus in people with HIV: A longitudinal study.HIV medicine · 2025Article
- Association of human immunodeficiency virus with acute myocardial infarction and presumed sudden cardiac death.Resuscitation plus · 2025Article
- Types of Myocardial Infarction in People With HIV in Switzerland.Open forum infectious diseases · 2025Article
- Understanding barriers and facilitators to integrated HIV and hypertension care in South Africa.Implementation science communications · 2024Article
- Quantification of subclinical plaque characteristics and perivascular fat using coronary computed tomography angiography (CCTA) among individuals with human immunodeficiency virus (HIV).Quantitative imaging in medicine and surgery · 2024Article
- Comparison of Three Cardiovascular Risk Scores among HIV-Infected Patients in Korea: The Korea HIV/AIDS Cohort Study.Infection & chemotherapy · 2022Article
- Factors associated with adherence to guideline-recommended cardiovascular disease prevention among HIV clinicians.Translational behavioral medicine · 2022Article
- HIV-1 and human genetic variation.Nature reviews. Genetics · 2021Review
- Acute myocardial infarction associated with abacavir and tenofovir based antiretroviral drug combinations in the United States.AIDS research and therapy · 2021Article
- Coronary Artery Disease: Association Study of 5 Loci with Angiographic Indices of Disease Severity.Disease markers · 2021Article
- Longitudinal Progression of Subclinical Coronary Atherosclerosis in Swiss HIV-Positive Compared With HIV-Negative Persons Undergoing Coronary Calcium Score Scan and CT Angiography.Open forum infectious diseases · 2020Article
- HIV Infection and Long-Term Residual Cardiovascular Risk After Acute Coronary Syndrome.Journal of the American Heart Association · 2020Observational
- Minding the gap in HIV host genetics: opportunities and challenges.Human genetics · 2020Review
- Subclinical Atherosclerosis Imaging in People Living with HIV.Journal of clinical medicine · 2019Review
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78 authors at 20 institutions in 10 countries.
Funding
Abstract
backgroundPersons infected with human immunodeficiency virus (HIV) have increased rates of coronary artery disease (CAD). The relative contribution of genetic background, HIV-related factors, antiretroviral medications, and traditional risk factors to CAD has not been fully evaluated in the setting of HIV infection.
methodsIn the general population, 23 common single-nucleotide polymorphisms (SNPs) were shown to be associated with CAD through genome-wide association analysis. Using the Metabochip, we genotyped 1875 HIV-positive, white individuals enrolled in 24 HIV observational studies, including 571 participants with a first CAD event during the 9-year study period and 1304 controls matched on sex and cohort.
resultsA genetic risk score built from 23 CAD-associated SNPs contributed significantly to CAD (P = 2.9 × 10(-4)). In the final multivariable model, participants with an unfavorable genetic background (top genetic score quartile) had a CAD odds ratio (OR) of 1.47 (95% confidence interval [CI], 1.05-2.04). This effect was similar to hypertension (OR = 1.36; 95% CI, 1.06-1.73), hypercholesterolemia (OR = 1.51; 95% CI, 1.16-1.96), diabetes (OR = 1.66; 95% CI, 1.10-2.49), ≥ 1 year lopinavir exposure (OR = 1.36; 95% CI, 1.06-1.73), and current abacavir treatment (OR = 1.56; 95% CI, 1.17-2.07). The effect of the genetic risk score was additive to the effect of nongenetic CAD risk factors, and did not change after adjustment for family history of CAD.
conclusionsIn the setting of HIV infection, the effect of an unfavorable genetic background was similar to traditional CAD risk factors and certain adverse antiretroviral exposures. Genetic testing may provide prognostic information complementary to family history of CAD.
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