ArticleIntensive care medicine2013
Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio.
Article in Intensive care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 109 citations in OpenAlex.
- Noninvasive oxygenation monitoring in PPHN: validation of the oxygen saturation index and the oxygen saturation to fraction of inspired oxygen ratio against conventional invasive indices.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Development of a predictive model for high-flow nasal cannula treatment failure in emergency department patients with acute heart failure: a retrospective secondary data analysis.Journal of Korean biological nursing science · 2026Article
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- Implications of sedation during the use of noninvasive ventilation in children with acute respiratory failure (SEDANIV Study).Critical care (London, England) · 2024Observational
- Novel Oxygenation and Saturation Indices for Mortality Prediction in COVID-19 ARDS Patients: The Impact of Driving Pressure and Mechanical Power.Journal of intensive care medicine · 2024Article
- Comparison of the Efficacies of High-Flow Nasal Cannula Oxygen Therapy and Non-invasive Nasal Cannula Ventilation in Preventing Intubation.Turkish archives of pediatrics · 2024Article
- Associations With Severe Desaturation Events Among Children Receiving Noninvasive Respiratory Support at Time of Intubation.Respiratory care · 2023Article
- Description and Validation of a Novel Score (Flow Index) as a Clinical Indicator of the Level of Respiratory Support to Children on High Flow Nasal Cannula.Journal of pediatric intensive care · 2023Article
- Quality Improvement Initiative to Improve Initiation and Acceptability of Noninvasive Ventilation in Critically Ill Children.Indian journal of pediatrics · 2022Article
- Predictors of high-flow nasal cannula failure in pediatric patients with acute respiratory distress.Clinical and experimental pediatrics · 2022Article
- Development of a deep learning model that predicts Bi-level positive airway pressure failure.Scientific reports · 2022Article
- Article
- A multicentered study on efficiency of noninvasive ventilation procedures (SAFE-NIV)Turkish journal of medical sciences · 2021Observational
- Kartagener syndrome: A case report.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2021Article
- Extended use of the modified Berlin Definition based on age-related subgroup analysis in pediatric ARDS.Wiener medizinische Wochenschrift (1946) · 2019Article
- Sepsis and Pediatric Acute Respiratory Distress Syndrome.Journal of pediatric intensive care · 2019Review
- Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study.The Lancet. Respiratory medicine · 2019Observational
- Noninvasive ventilation as the first choice of ventilatory support in children.Revista Brasileira de terapia intensiva · 2019Article
- Noninvasive Ventilation and High-Flow NasalSultan Qaboos University medical journal · 2018Review
- Risk stratification using SpOAnnals of intensive care · 2017Article
Corrections and comments
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Authors and funding
17 authors at 14 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOur objective was to assess whether SpO₂/FiO₂ (SF) ratio could be a useful NIV outcome predictor in children with acute respiratory failure (ARF) and tried to develop a predictive model of NIV failure.
methodsProspective, observational, multicenter study. Episodes of ARF-fulfilling inclusion criteria from 15 January 2010 to 14 January 2011 were treated with NIV according to a pre-established protocol. Clinical variables were collected at baseline and at 1, 2, 6, 12 and 24 h. Failure criterion was the need for endotracheal intubation. Failures were considered as "early" if occurring ≤6 h after NIV initiation, "intermediate" if occurring between 6 and 24 h, and "late" if occurring after 24 h. Variables with a p < 0.1 in univariate analysis corrected by age were included in multivariate analysis. Models were calculated based on multivariate analysis.
resultsDuring the study period, 390 episodes were included. NIV success rate was 81.3 %. Among ARF causes, failure occurred most frequently in ARDS episodes. The failure predictive model for the whole sample included SF ratio at 1 h, age and PRISM III-24 (area under the curve AUC of 0.755). For early NIV failures, SF ratio at 1 h was the only variable within model (AUC 0.748). The analysis of intermediate NIV failures identified 3 variables independently linked to NIV outcome: PRISM III-24, RR decrease at 6 h, and SF ratio at 6 h (AUC 0.895). No model was identified for late NIV failure.
conclusionsSF ratio is a reliable predictor of early NIV failure in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.